17 August 2026
: Case report 
A Case Report of a 64-Year-Old Man With Urothelial Carcinoma With Brain and Leptomeningeal Metastases Treated With Intrathecal Methotrexate as Part of Multimodal Management
Unusual or unexpected effect of treatment, Rare disease
Leland F. Damron ABCDEF 1, Leigh Kinney ADEF 1, Nikhita Kathuria-Prakash ADEF 2, Marilena Iliopoulos EF 3, Dimitrios Stefanoudakis EF 4, Lidia P. Lopez BDEF 2, Marah Sakkal
BE 5, Negar Khanlou BCD 6, Steven D. Hart BCD 6, Neda A. Moatamed BCD 6, Nicolaos J. Palaskas AEF 2, Alexandra Drakaki ACDEG 2,4*
DOI: 10.12659/AJCR.951572
Am J Case Rep 2026; 27:e951572
Figure 3 Histopathologic confirmation of pulmonary metastasis from urothelial carcinoma. (A) A high power (200×) hematoxylin and eosin (H&E)-stained section showing tumor cells with round-to-oval central nuclei and moderate amounts of eosinophilic cytoplasm, consistent with urothelial origin. (B) A low power (100×) H&E-stained section showing lung parenchyma with sheets of neoplastic cells within alveolar spaces. (C) GATA3 positive nuclear staining supportive of urothelial origin (GATA3 IPOX 100×).