17 August 2026
: Case report 
A Case Report of a 64-Year-Old Man With Urothelial Carcinoma With Brain and Leptomeningeal Metastases Treated With Intrathecal Methotrexate as Part of Multimodal Management
Unusual or unexpected effect of treatment, Rare disease
Leland F. Damron ABCDEF 1, Leigh Kinney ADEF 1, Nikhita Kathuria-Prakash ADEF 2, Marilena Iliopoulos EF 3, Dimitrios Stefanoudakis EF 4, Lidia P. Lopez BDEF 2, Marah Sakkal
BE 5, Negar Khanlou BCD 6, Steven D. Hart BCD 6, Neda A. Moatamed BCD 6, Nicolaos J. Palaskas AEF 2, Alexandra Drakaki ACDEG 2,4*
DOI: 10.12659/AJCR.951572
Am J Case Rep 2026; 27:e951572
Figure 4 Histopathologic findings of brain metastasis. (A, B) Hematoxylin and eosin (H&E) histopathology at 100× and 200× power showing sheets of neoplastic epithelioid cells with moderately pleomorphic, enlarged nuclei and prominent nucleoli. Mitotic figures are present. Reactive gliosis is present in the surrounding brain tissue. (C) Nuclear immunoreactivity with antibody to GATA3 is consistent with the known urothelial origin.