14 March 2026
: Case report 
A 43-Year-Old Man With Isolated Cutaneous Lymphomatoid Granulomatosis Presenting as a Chronic Necrotizing Ulcer of the Upper Arm
Challenging differential diagnosis, Rare disease, Educational Purpose (only if useful for a systematic review or synthesis)
Adebola Oluwabusayo Adetiloye
EF 1*, Anim Asif E 1, Olurotimi J. Badero EF 2, Tan Zimri E 1, Nadine C. Brissett-Williams E 1
DOI: 10.12659/AJCR.951661
Am J Case Rep 2026; 27:e951661
Figure 4 Representative excerpt from a clinically obtained next-generation sequencing report performed on the patient’s cutaneous biopsy specimen, demonstrating EBV-associated lymphoproliferative disorder consistent with grade 3 lymphomatoid granulomatosis and absence of clinically actionable lymphoma-associated mutations. The analysis demonstrated an ATM p. (Asn2282Ser) variant of unknown clinical significance, with no clinically relevant mutations detected in a panel of lymphoma-associated genes (including TP53, BCL2, MYC, and JAK2). Histopathology confirmed tumor involvement comprising >50% of nuclei in the sample.