15 May 2026
: Case report 
A 56-Year-Old Woman With Systemic Lupus Erythematosus on Trimethoprim-Sulfamethoxazole Prophylaxis Presenting With Breakthrough Nocardiosis
Unusual clinical course, Challenging differential diagnosis, Unusual or unexpected effect of treatment
Ming Lu BCE 1,2, Jingwen Zhang BCF 3,4, Ying Liu CD 5, Feng Nie BC 6,4, Tianyu Zou BC 1,4, Haijun Li CD 7, Ping Li ABEG 1,2*, Tianxin Xiang ABEF 2,6DOI: 10.12659/AJCR.952006
Am J Case Rep 2026; 27:e952006
Figure 6 Follow-up chest computed tomography scans after 10 days of escalated antimicrobial therapy with high-dose trimethoprim-sulfamethoxazole (TMP-SMX, three tablets orally 3 times daily) combined with linezolid (600 mg orally twice daily) (December 21, 2024). (A–E) Lung window images demonstrate a significant reduction in the extent and density of previously observed consolidations and nodular opacities in the right upper lobe, indicating a positive therapeutic response.