15 May 2026
: Case report 
A 56-Year-Old Woman With Systemic Lupus Erythematosus on Trimethoprim-Sulfamethoxazole Prophylaxis Presenting With Breakthrough Nocardiosis
Unusual clinical course, Challenging differential diagnosis, Unusual or unexpected effect of treatment
Ming Lu BCE 1,2, Jingwen Zhang BCF 3,4, Ying Liu CD 5, Feng Nie BC 6,4, Tianyu Zou BC 1,4, Haijun Li CD 7, Ping Li ABEG 1,2*, Tianxin Xiang ABEF 2,6DOI: 10.12659/AJCR.952006
Am J Case Rep 2026; 27:e952006
Figure 7 A Follow-up chest computed tomography scans after one month of antimicrobial therapy with high-dose TMP-SMX monotherapy (three tablets orally three times daily), following discontinuation of linezolid due to limited access in the patient’s rural residence and confirmed TMP-SMX susceptibility (January 5, 2025). (A–F) Lung window images show a continued significant reduction in the extent and density of consolidations and nodular opacities in the right upper lobe, indicative of sustained therapeutic response.