21 August 2026
: Case report 
Histiocytic Sarcoma With Striking Clinical Improvement
Challenging differential diagnosis, Unusual or unexpected effect of treatment, Rare disease
Nur Farhanah
EF 1*, Jessica Novia Hadiyanto F 2, Erlieza Roosdhania F 3, Dhesi Ariembi B 4, Enny Puji Astuti B 5, Subiyakto Bustomi F 6, Eny Dyah Kurniawati F 7, Hermawan Istiadi F 8, Budi Setiawan F 9
DOI: 10.12659/AJCR.952214
Am J Case Rep 2026; 27:e952214
Figure 1 The lesions are observed on the thorax (A) and back (B). Nodular and crateriform lesions characterized by central keratosis, crust, and erythematous-violaceous infiltrated edges. Clinical presentation of the lesions before and after 6 months of observation under a watch-and-wait approach. There is a significant reduction in lesion size and improvement in the skin’s overall condition.