Histiocytic Sarcoma With Striking Clinical Improvement

Nur Farhanah; Jessica Novia Hadiyanto; Erlieza Roosdhania; Dhesi Ariembi; Enny Puji Astuti; Subiyakto Bustomi; Eny Dyah Kurniawati; Hermawan Istiadi; Budi Setiawan

doi:10.12659/AJCR.952214

21 August 2026 : Case report Indonesia

Histiocytic Sarcoma With Striking Clinical Improvement

Challenging differential diagnosis, Unusual or unexpected effect of treatment, Rare disease

Nur Farhanah

^{EF 1*}, Jessica Novia Hadiyanto

^{F 2}, Erlieza Roosdhania

^{F 3}, Dhesi Ariembi

^{B 4}, Enny Puji Astuti^{B 5}, Subiyakto Bustomi

^{F 6}, Eny Dyah Kurniawati

^{F 7}, Hermawan Istiadi

^{F 8}, Budi Setiawan

^{F 9}

DOI: 10.12659/AJCR.952214

Am J Case Rep 2026; 27:e952214

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Figure 3 The immunohistochemical findings support the diagnosis of histiocytic sarcoma, with positive staining for (A) CD68 (histiocytic marker), (B) CD45 (hematopoietic origin), and a high proliferation index with (C) Ki67 (60–70%). Negative results for (D) CD3, (E) CD20, (F) CD30, CD34, and S100 exclude lymphoma, dendritic neoplasms, and Langerhans cell tumors.

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Histiocytic Sarcoma With Striking Clinical Improvement

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