28 August 2026
: Case report 
Aggressive Sporadic Renal Angiomyolipoma With Tumor Thrombus Extending Into the Inferior Vena Cava, Right Atrium, and Right Ventricle: A Multidisciplinary Case Report
Unusual clinical course, Challenging differential diagnosis, Unusual setting of medical care
Caroline J. Cushman
ABCDEF 1*, Kolos K. Nagy EF 1, Rodolfo Martinez D 2, Kaiser R. Tarafdar ABCDEF 3
DOI: 10.12659/AJCR.952664
Am J Case Rep 2026; 27:e952664
Figure 4 Histopathologic findings of renal angiomyolipoma. Low-power hematoxylin and eosin (H&E) section demonstrates classic triphasic morphology with an admixture of mature adipose tissue, thick-walled blood vessels, and smooth muscle bundles (× 40). Higher-magnification view highlights perivascular epithelioid cells with clear cytoplasm and mild nuclear pleomorphism (× 200). Immunohistochemical staining demonstrates positivity for HMB-45 and smooth muscle actin, confirming the diagnosis of angiomyolipoma.