25 August 2026
: Case report 
Pilomatricoma in an Octogenarian: A Case Report of an Exceptional Late-Life Presentation
Unusual clinical course, Challenging differential diagnosis
Oliwia Gunia BCEF 1*, Maëlys Bresson BCEF 1, Claude Depardieu BCD 1, Gilles Dolivet AB 1,2, Giacomo Gravante CD 3, Romina Mastronicola ABCDEFG 1,2DOI: 10.12659/AJCR.953320
Am J Case Rep 2026; 27:e953320
Figure 2 Histopathological section: (A) H&E: Well-circumscribed, lobulated dermal neoplasm. At the cellular level, it shows islands of basaloid cells with mitotic activity, exhibiting abrupt keratinization into anucleated ghost cells. The tumor keratin has elicited a foreign-body giant cells granulomatous inflammatory response. No signs of invasion or atypical features are present. (B) Immunohistochemistry (beta-catenin): Low-power view showing nuclear and membranous positivity. The areas of shadow cells and keratins remain negative.