24 September 2026
: Case report 
Giant Well-Differentiated Liposarcoma of the Spermatic Cord Associated With Inguinal Hernia: Clinical Insights From a Case Report
Challenging differential diagnosis, Rare disease
Kristian Chrz
ABCDE 1,2*, David Hoskovec ABDE 1,2, Zdeněk Krška ADG 1,2, M.E. Dämmrich BDF 3, Pavol Klobušický ABCDEF 2,4
DOI: 10.12659/AJCR.953433
Am J Case Rep 2026; 27:e953433
Figure 3 Histological specimen (H&E): In the upper section of the image, the normal adipose tissue of the well-differentiated liposarcoma can be seen, exhibiting a harmonious structure (R0 Grade 1 UICC). In the lower section, the neoplastic tissue is evident, characterized by numerous mitoses and nuclear polymorphisms, displaying pleomorphic cellular morphology. [A] Liposarcoma G1 Structure; [B] Neoplastic Lipoblasts and Lipocytes; [C] Analyzing immunohistochemistry (IHC): S100+, MDM2+, CDK4+.