27 September 2026
: Case report 
Pulmonary Actinomycosis Diagnosed via BALF mNGS in a 53-Year-Old Nonsmoking Man With Pneumoconiosis and Penicillin-Induced Thrombocytopenia: A Case Report
Unusual clinical course, Challenging differential diagnosis, Unusual or unexpected effect of treatment, Adverse events of drug therapy, Educational Purpose (only if useful for a systematic review or synthesis), Rare coexistence of disease or pathology
Xin Feng BE 1, Lin-yu Wang
CE 2, Ni-jiao Li DE 1, Ze-qiang Lin F 1, He-ming Huang F 1, Yi-ling Xie F 1, Jie Liang F 1, Lunkai Yao F 1, Xin-yi Zhuo F 1, Yan Li DF 2*, Ye Qiu AG 1
DOI: 10.12659/AJCR.953438
Am J Case Rep 2026; 27:e953438
Figure 3 Serial BALF mNGS resultsImage shows BALF mNGS findings from admission day 15 (A), and 3-month follow-up (B). In panel A, Actinomyces israelii was identified as a suspected pathogenic microorganism, with 32 sequence reads. In panel B, Actinomyces israelii was identified as a pathogenic microorganism, with 31 sequence reads. Abbreviations: BALF, bronchoalveolar lavage fluid; mNGS, metagenomic next-generation sequencing.