01 September 2026
: Case report 
Combination of Multiple-Dose Activated Charcoal and Infusion Therapy That Led to Favorable Outcomes in Colchicine Poisoning: A Case Report
Unknown etiology, Management of emergency care
Manabu Eiraku AB 1, Kazuyuki Miyamoto E 1,2*, Keisuke Suzuki
B 1, Kazumasa Abe C 3, Tatsuro Tamatsukuri D 3, Asuka Kaizaki-Mitsumoto CDE 4, Kazuki Kikuchi B 1, Masaharu Yagi B 1, Satoshi Numazawa CD 4, Kenji Dohi DE 1
DOI: 10.12659/AJCR.953541
Am J Case Rep 2026; 27:e953541
Figure 1 Serial serum and urine colchicine concentrations (ng/mL) plotted against hours post ingestion (h-PI). Key interventions are annotated on the time axis: activated charcoal and laxative (27 h-PI), multiple-dose activated charcoal doses (27–101 h-PI, every 6 h), infusion rate changes, HD (48.0–52.2 h-PI), HDF1 (70.8–74.6 h-PI), and HDF2 (97.9–102.0 h-PI). Timed urine specimens were used for all points except the final specimen at 117 h-PI (spot urine). Pre-HD serum samples were obtained via circuit line; post-HDF samples were peripheral vein obtained 2.4 h (HDF1) and 11 h (HDF2) after session completion.