31 August 2026
: Case report 
Radiation Associated Undifferentiated Pleomorphic Sarcoma of the Neck 2 Decades After External Beam Radiation for Medullary Thyroid Carcinoma: A Case Report and Literature Review
Unusual clinical course, Challenging differential diagnosis, Rare disease
Tanya Odisho ABDEF 1,2, Sedighe Esmaeilzade
ABDEF 3, Alexander Laskaris BEF 2, Sungmi Jung ABDEF 4, James Man Git Tsui DEF 1,3, Sinziana Dumitra ABDEF 5,2, Elliot Mitmaker ABDEF 1,2*
DOI: 10.12659/AJCR.953580
Am J Case Rep 2026; 27:e953580
Figure 1 CT imaging showing the progression of neck soft tissue masses. In 2002, a 12-mm nodule was identified in the left thyroid lobe (A), along with multiple bilateral nodes suggestive of metastases, the largest in the jugulodigastric and right omohyoid regions measuring 16 mm (B). Images from 2025 after remission reveal a well-defined 1.9 × 1.7 × 1.5 cm lesion inferior to the right submandibular space, suspected enlarged lymph node with extracapsular extension (C). Postsurgical imaging shows resection of a right cervical sarcomatous mass between the right hyoid and thyroid cartilages (D).