31 August 2026
: Case report 
Radiation Associated Undifferentiated Pleomorphic Sarcoma of the Neck 2 Decades After External Beam Radiation for Medullary Thyroid Carcinoma: A Case Report and Literature Review
Unusual clinical course, Challenging differential diagnosis, Rare disease
Tanya Odisho ABDEF 1,2, Sedighe Esmaeilzade
ABDEF 3, Alexander Laskaris BEF 2, Sungmi Jung ABDEF 4, James Man Git Tsui DEF 1,3, Sinziana Dumitra ABDEF 5,2, Elliot Mitmaker ABDEF 1,2*
DOI: 10.12659/AJCR.953580
Am J Case Rep 2026; 27:e953580
Figure 2 Histopathology of the resected mass. A 4.0-cm relatively well-circumscribed tumor was excised (A). The tumor displays a pattern less arrangement of atypical spindled cells with no identifiable line of differentiation (B). Immunohistochemical stains confirm no evidence of thyroid cell differentiation and no reactivity for calcitonin depicted (C).