Logo American Journal of Case Reports

Call: 1.631.629.4328
Mon-Fri 10 am - 2 pm EST

Contact Us

Logo American Journal of Case Reports Logo American Journal of Case Reports Logo American Journal of Case Reports

15 July 2020: Articles  United Kingdom

Peculiar Skin Rash After Laparoscopic Sleeve Gastrectomy

Unusual clinical course

Mohamed Eghleilib1ABCDEF*, Ahmed Eghlileb2ABCDEF, Ihasan Al-Alem3ABCDEF, Dalia Sriwi4DEFG, Amany Khaled Elshaer4DEFG

DOI: 10.12659/AJCR.920728

Am J Case Rep 2020; 21:e920728



BACKGROUND: Obesity is one of the leading causes of preventable death worldwide. Due to its increasing incidence and the difficulty in reducing its morbidity and mortality using nonsurgical methods, the demand for bariatric surgery has risen in recent times. Sleeve gastrectomy is one of the most common types of bariatric surgery, and like any other surgery, it carries a series of risks.

CASE REPORT: Although complications such as gastrointestinal leaks are widely reported, there is limited literature available on cutaneous complications. Here, we report 4 cases of patients showing a peculiar skin rash 2–4 weeks following sleeve gastrectomy. We also discuss some of the mechanisms that may underlie this correlation.

CONCLUSIONS: There is a need for further epidemiological studies to determine the prevalence of this rash. Further studies are also needed to determine the exact etiology of this rash.

Keywords: Bariatric Surgery, Gastrectomy, Obesity, Morbid, Dermatitis, Exanthema, folliculitis, Postoperative Complications


Obesity is one of the biggest health problems in the modern age. It has a massive impact on both morbidity and mortality. Not only does it increase the risk of diabetes and cardiovascular disease, it is now one of the leading causes of death worldwide [1]. Many approaches have been used to reduce obesity and its catastrophic effects on today’s society, including education, dieting, exercise, and drugs. However, with its increasing incidence and severity, these nonsurgical methods do not suffice for some patients, so the demand for bariatric surgery has risen [2].

There are 3 main types of bariatric surgery:Restrictive procedures: including laparoscopic adjustable gastric banding, laparoscopic sleeve gastrectomy, and vertical banded gastroplasty. These procedures effectively reduce the gastric lumen to induce early satiety [1,2].Malabsorptive procedures: including jejunoileal bypass, which aims to decrease the amount of nutrients absorbed by reducing the surface area of the intestine exposed to food [1,2].Combined restrictive-malabsorptive procedures: including Roux-en-Y gastric bypass [1,2].

Despite their ability to aid weight loss and improve mortality and morbidity rates in previously morbidly obese individuals, bariatric surgery can result in a range of complications. Although complications such as gastrointestinal leaks and intraabdominal abscesses are widely reported, [3,4] there is limited literature available on cutaneous complications. Here, we report 4 cases of patients with no other significant medical history showing a peculiar skin rash 2–4 weeks following sleeve gastrectomy, the most common subtype of bariatric surgery. The 4 patients were of Saudi Arabian descent, seen at the Suwaidi Hospital of the Habib Medical Group, Riyadh.

Because the clinical state of the presenting skin rash is rapidly self-limiting, the significance of this topic is more deeply rooted in academic interest. Nonetheless, by defining the rash and determining its association with sleeve gastrectomy, it may be possible to target it for treatment and to implement prophylactic measures before any visible dermatological manifestations occur. More broadly, defining this condition provides a basis for recognition by doctors in order to alert bariatric patients of this possible adverse effect of surgery, thereby improving doctor-patient trust by transparency.

Case Reports


A 25-year-old man presented with a history of extensive multiple maculopapular erythematous skin rash, which started 3 weeks after sleeve gastrectomy. Before the surgery, a vitamin B12 injection was given to the patient prophylactically. There were no trace elements or vitamin deficiencies present at this time (including vitamin A and zinc). After the surgery, the rash presented all over the body, starting on the chest, spreading to the face, buttocks, trunk, and upper limbs. The rash had 2 distinguishable morphologies – the lesion on the face was clinically typical of a folliculitis rash (Figure 1B), but the remaining lesions, including the abdomen and the back (where the biopsies were taken), revealed spongiotic dermatitis (Figure 1A, 1C). The histopathology analysis showed parakeratosis with underlying interface lymphocytic infiltrate associated with vacuolar degeneration of basal cells, necrotic keratinocytes, extravasated red blood cells, perivascular lymphocytes, and scattered eosinophils. Therefore, a diagnosis of dermatitis of the trunk was made. A biopsy of the facial lesions was not taken. Apart from slightly low vitamin D levels, blood tests were unremarkable. And, apart from a previously high BMI (42 Kg/m2), the patient was otherwise well, with no signs of insulin resistance, hyper-tension, or hypercholesterolemia. The patient had no known allergies. Betamethasone and fusidic acid were given for the body rash and Clindamycin solution was given for the face rash. This produced a dramatic improvement by the second visit.


A 29-year-old man presented with a history of sudden eruption of maculopapular erythematous lesions, mainly on the face, neck, and upper chest, 3 weeks after sleeve gastrectomy (Figure 2). Clinically, a preliminary diagnosis of folliculitis was made. The surgery was performed in Jordan 3 weeks prior to consultation. His medical records showed a previous BMI of 40 kg/m2, without any co-morbidities. Blood tests were unre-markable, including normal vitamin and trace element levels. The were no known allergies. To confirm the post-surgical rash, a punch biopsy performed, which showed moderate inflammatory infiltrate of neutrophils and lymphocytes in the follicular ostium, confirming the diagnosis. The patient was started on Vibramycin 100 mg once a day for a month with betamethasone and fusidic acid cream twice a day for the upper chest and Clindamycin for the face. The patient came for a checkup 3 weeks later, showing complete healing (Figure 3), and was therefore discharged.


A 39-year-old woman presented with a sudden eruptive rash on the upper chest and both sides of the neck just 2 weeks after a sleeve gastrectomy (previous BMI 40 Kg/m2). The rash displayed an erythematous follicular pattern, indicating folliculitis (Figure 4). We requested a biopsy to confirm the diagnosis, but this was unfortunately refused by the patient. Before surgery, vitamin and trace element levels were normal, and prophylactic supplements of vitamin B12 were given. After the surgery, blood tests were unremarkable. The patient had no known allergies. Vibramycin 100 mg once a day was given for 2 weeks, with betamethasone and fusidic acid cream twice daily. The patient returned 2 weeks later with complete healing of lesions but with post-inflammatory hyperpigmentation. Whitening cream was given, which was very effective.


A 32-year-old man presented with a severe eruptive rash on his trunk, chest, and face, which developed 4 weeks after sleeve gastrectomy (previous BMI 40 kg/m2). The lesions in this patient were also follicular (Figure 5), which was later confirmed by histology. Like the previous patients, there were no known co-morbidities or allergies, and blood tests were unremarkable before and after surgery. Doxycycline 100 mg once a day was given for 1 month with Clindamycin solution. The patient returned in 3 weeks with complete healing.



The sample size here is very small, only including 4 reported cases. Therefore, although 75% of patients presented with folliculitis in this report, the population from which the patients were sampled may show a stronger weighting towards dermatitis. Secondly, we need to acknowledge that patients were assessed under the umbrella term of folliculitis, when subtype stratification may also be important. This is important because the known etiology of these conditions is not the same; therefore, the mechanisms underlying the possible association between bariatric surgery and folliculitis may be different. Nonetheless, despite these differences, the common denominator is skin manifestations in a large proportion of patients after bariatric surgery, manifesting within 4 weeks. Hence, this may be a unifying mechanism, as discussed.

Thirdly, all patients reported were of the same Saudi Arabian ethnicity, but it is known that the distribution of skin conditions varies with ethnicity, with a role for both genetics and the environment. We also did not control for confounding by lifestyle factors. This is significant, especially given that it is understood that various factors such as stress, smoking, and diet can have a range of effects on the skin. Furthermore, patients in need of bariatric surgery were randomly sampled, and pre-surgical factors of weight, body mass index (BMI), and secondary conditions were not taken into account. For example, one of the cases had his surgery abroad in Jordan, where the criteria for bariatric surgery appear to differ. Finally, the follow-up only extended as far as hospital visits for therapy. More specifically, it was assumed in the patient with post-surgical dermatitis that there was complete elimination of the skin rash, but without follow-up, there is no confirmation.

Finally, we must take care in extrapolating our findings to all patients developing a skin rash following bariatric surgery, especially given that some evidence shows variation in cutaneous manifestation between the subtypes of bariatric surgeries. For example, Shope et al. found that there is an increased incidence of infection in circular-stapled anastomoses compared to linear-stapled anastomoses in laparoscopic Rouxen-Y gastric bypass [14].


As a result of the increase in incidence in bariatric surgery, rarer and less frequent complications of these procedures are more likely to become apparent. Here, we describe a possible complication of a peculiar rash developing several weeks after surgery. Currently, we only have a collection of case studies with a few plausible explanations for this presentation. However, the clinical significance (if any) of this relationship needs to be assessed by further epidemiological studies and randomized clinical trials. After defining this association and its pathogenesis, we might be able to treat it effectively and ultimately prevent it.


1.. Halawi A, Abiad F, Abbas O, Bariatric surgery and its effects on the skin and skin diseases: Obes Surg, 2013; 23(3); 408-13

2.. Paula A, Manzoni S, Weber M, Skin changes after bariatric surgery: An Bras Dermatol, 2015; 90(2); 157-66

3.. Papavramidis T, Complications after vertical gastroplasty artificial pseudo-pylorus in the treatment morbid obesity: A 7-year experience: Obes Surg, 1999; 9(6); 535-38

4.. Mason E, Renquist E, Perioperative risks and safety of surgery for severe obesity: Am J Clin Nutr, 1992; 55(2); 573S-76S

5.. Shipman A, Millington GWM, Millington G, Obesity and the skin: Br J Dermatol, 2011; 165(4); 743-50

6.. Michaels J, Coon D, Rubin J, Complications in postbariatric body contouring: Postoperative management and treatment: plastic and reconstructive surgery, 2011; 127(4); 1693-700

7.. Monshi B, Vigl K, Weihsengruber F, Phrynoderma and acquired acrodermatitis enteropathica in breastfeeding women after bariatric surgery: J Dtsch Dermatol Ges, 2015; 13(11); 1147-54

8.. Farias MM, Gajardo C, Alvarez V, Short-term skin reactions associated to sleeve gastrectomy in eight patients: Obes Surg, 2014; 24(10); 1826-29

9.. Stephan F, Haber R, Maalouf D, Tomb R, A case of dermatitis herpetiformis after a mini-gastric bypass surgery: J Am Acad Dermatol, 2014; 71(1); e18-20

10.. Gao J, Zhang M, Zhu C, The change in the percent of android and gynoid fat mass correlated with increased testosterone after laparoscopic sleeve gastrectomy in Chinese obese men: A 6-month follow-up: Obes Surg, 2018; 28(7); 1960-65

11.. Arora MK, Yadav A, Saini V, Role of hormones in acne vulgaris: Clin Biochem, 2011; 44(13); 1035-40

12.. Poutahidis T, Springer A, Levkovich T, Probiotic microbes sustain youthful serum testosterone levels and testicular size in aging mice: PLoS One, 2014; 9(1); e84877

13.. Ridlon JM, Ikegawa S, Alves J: J Lipid Res, 2013; 54(9); 2437-49

14.. Shope TR, Cooney RN, Mcleod J: Obes Surg, 2003; 13(3); 355-59

In Press

12 Mar 2024 : Case report  Japan

Successful Treatment of Lithium-Induced Nephrogenic Diabetes Insipidus with Celecoxib: A Promising Therapeu...

Am J Case Rep In Press; DOI: 10.12659/AJCR.943244  


13 Mar 2024 : Case report  Taiwan

Recurrent Marginal Zone Lymphoma with Bone Marrow Involvement Detected by ¹⁸F-FDG PET/CT and Biopsy: A Diag...

Am J Case Rep In Press; DOI: 10.12659/AJCR.943275  

13 Mar 2024 : Case report  Denmark

Unveiling the Temporal Aspect of MRI Tattoo Reactions: A Prospective Evaluation of a Newly-Acquired Tattoo ...

Am J Case Rep In Press; DOI: 10.12659/AJCR.943411  

13 Mar 2024 : Case report  Singapore

Cardiac and Intramuscular Metastases Following Nephroureterectomy for Metachronous Urothelial Carcinoma

Am J Case Rep In Press; DOI: 10.12659/AJCR.942864  

Most Viewed Current Articles

07 Mar 2024 : Case report  USA

Neurocysticercosis Presenting as Migraine in the United States

DOI :10.12659/AJCR.943133

Am J Case Rep 2024; 25:e943133


10 Jan 2022 : Case report  Germany

A Report on the First 7 Sequential Patients Treated Within the C-Reactive Protein Apheresis in COVID (CACOV...

DOI :10.12659/AJCR.935263

Am J Case Rep 2022; 23:e935263

19 Jul 2022 : Case report  Saudi Arabia

Atlantoaxial Subluxation Secondary to SARS-CoV-2 Infection: A Rare Orthopedic Complication from COVID-19

DOI :10.12659/AJCR.936128

Am J Case Rep 2022; 23:e936128

23 Feb 2022 : Case report  USA

Penile Necrosis Associated with Local Intravenous Injection of Cocaine

DOI :10.12659/AJCR.935250

Am J Case Rep 2022; 23:e935250

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923