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22 March 2022: Articles  USA

Lambl’s Excrescences Associated with Cardioembolic Stroke

Rare disease

Biraj Shrestha ORCID logo1EF*, Arpan Pokhrel1F, Ibiyemi Oke1F, Anish Paudel1E, Bidhya Timlisina1E, Prem Parajuli1E, Sijan Basnet1E, Bidhya Poudel2E

DOI: 10.12659/AJCR.934859

Am J Case Rep 2022; 23:e934859



BACKGROUND: Lambl’s excrescences (LE) are threadlike fronds that occur along valve closure lines where minor endothelial damage occurs, resulting in thrombus formation. It is often asymptomatic but can result in cerebral embolism and coronary artery obstruction. The criterion standard for diagnosis is transesophageal echocardiography.

CASE REPORT: We report an interesting case of a 73-year-old right-handed man presenting with a visual disturbance. An MRI head demonstrated an acute-to-subacute infarct in the right posterior cerebral artery territory involving the posterior right temporal, right occipital lobes, and right thalamus, which was in keeping with embolic stroke. Investigation with transthoracic and transesophageal echocardiography showed echo density on the ventricle surface of the left coronary cusp, which was concerning for Lambl’s excrescences, with no significant arrhythmia on his implantable loop recorder at 3-month follow-up. Therefore, we believe that his stroke was due to embolization from Lambl’s excrescences. Since this was his first episode of stroke, monotherapy with aspirin was continued.

CONCLUSIONS: Although rare, Lambl’s excrescences should be considered in the differential diagnosis of embolic stroke. However, there is no established guideline for its management. Patients with the first stroke episode can be treated conservatively with antiplatelet therapy. In patients with recurrent ischemic events, anticoagulation should be offered, along with discussion about surgical excision.

Keywords: Echocardiography, Three-Dimensional, embolic stroke, Infarction, Posterior Cerebral Artery, Aged, Aortic Valve, Echocardiography, Transesophageal, Heart Valve Diseases, Humans, Male, Stroke


Cerebrovascular accident (CVA) is a leading cause of morbidity and mortality globally. However, among the 87% of ischemic stroke cases, cardiac embolism accounts for only 14–30% of all cases [1]. On the other hand, cryptogenic stroke represents 24–28% of all ischemic strokes, according to a meta-analysis reported by Ornello et al [2]. Lambl’s excrescences (LE) are a rare cause of embolic stroke, first described in 1856 by the Bohemian physician Vilém Dušan Lambl [3]. These are branched filiform structures with undulating movements on aortic and mitral valves. These are more common on the atrial side of the mitral valve (68–76%) followed by the ventricular side of the aortic valve (38–50%) [4]. Their pathogenesis remains uncertain and is believed to result from valvular wear and tear and have been considered to be part of normal aging. However, the clinical significance and effective treatment of LE remain controversial [3]. Here, we present an interesting case of a 73-year-old man presenting with visual deficits, found to have ischemic stroke thought to be secondary to LE.

Case Report

A 73-year-old right-handed man with a history of poorly controlled type 2 diabetes mellitus (HbA1C 10.4) on home insulin therapy presented to the Emergency Department (ED) after a fall associated with lightheadedness and nausea for 1 day. He also mentioned having visual disturbances in left upper visual fields for the same duration. Vitals were stable, and examination revealed a dense left homonymous hemianopsia and abnormal (ataxic) left finger-to-nose test. “Stroke alert” was called. Non-contrast computed tomography scan (CT) of the brain revealed acute right posterior cerebral artery distribution infarct (Figure 1).

He was not a candidate for intravenous tissue plasminogen activator as his last known well was greater than 4.5 h. CT angio-gram of the brain again showed ischemia in the right posterior cerebral artery distribution, with the suggestion of a right occipital and temporal lobe core infarct. CT angiogram of the neck did not show any hemodynamically significant vessel stenosis. Ultrasound Doppler of bilateral carotids was done, which showed plaque formation within both carotid bulbs, with 40% diameter stenosis. He was started on antiplatelet therapy with aspirin (ASA) and high-intensity statin. MRI angiography head (Figure 2) showed restricted diffusion in the right posterior cerebral artery involving the posterior right temporal, right occipital lobes, and right thalamus territory. This involvement of multiple vascular distributions was concerning for embolic stroke. A transthoracic echocardiogram (Figure 3) showed trace aortic insufficiency and a 6×3 mm echo density seen on the ventricle surface of the left coronary cusp, which was concerning for LE versus vegetation. Transesophageal echocardiography was done to further characterize the lesion, which confirmed a low-density, thin, hypermobile, filiform lesion on the ventricular surface of the aorta, consistent with LE. No atrial fibrillation was detected on telemetry monitoring during hospitalization. The patient underwent implantation of a loop recorder for long-term heart rhythm monitoring. On the day of discharge, the visual field cut on the left was unchanged from admission.

Our loop recorder interrogation at 1- and 3-month follow-up did not show any evidence of arrhythmias. At 6-month follow-up, the patient reported tolerating aspirin well, with slight improvement in visual symptoms and no new weakness. Therefore, we believe that his stroke could have been due to embolization from LE. Since this was his first episode of stroke, monotherapy with aspirin was continued with no further interventions.


Lambl’s excrescences (LE) are most commonly found on the atrial surface of the mitral valve (68–76%) and the ventricular surface of the aortic valve (38–50%) and have been rarely described on native right-sided valves and prosthetic valves [5].

The patient had echo density on the left coronary cusp in our case. These are primarily asymptomatic and may present as an incidental finding on echocardiography. However, LE can break off, as in our case, and lead to thromboembolic events. Ischemic events have been more reported with involvement of the aortic valve, and no correlation has been found between the size of strands and the incidence of stroke. Valvular strands can be detected on high-resolution transthoracic echocardiography (TTE), which appears at the leaflet coaptation as hyper-mobile, undulating, strand-like structures less than 2 mm thick more than 3 mm long along the valve closure [5]. Differential diagnosis includes imaging artifact, vegetations, thrombi, redundant leaflet, flap due to aortic dissection, papillary fibroelastoma, myxoma, other cardiac neoplasms, and metastases. Fibroelastomas are the most difficult to differentiate from LE. Notable differences from LE are multiple lesions and locations along the lining of the valve closure.

Fibroelastoma is solitary and larger, usually arising from the midportion of the valve leaflet, which at times can appear as a pedunculated lesion. In our case, the echocardiogram showed a low-density, thin, hypermobile, filiform lesion on the ventricular surface of the aorta along with the valve closure, consistent with LE. As in this case, high-resolution TTE can diagnose LE, but the criterion standard for diagnosis is transesophageal echocardiography (TEE), which can best define the lesion [4]. There is no standard evidence-based guideline in LE management, given the condition’s rarity. Management is based mainly on case reports and includes single/dual antiplatelet agent vs anticoagulation vs surgery [1]. An asymptomatic patient can be monitored closely and followed with transesophageal echo-cardiography (TEE). Chu et al suggest that LE should be considered in the differential diagnosis of cryptogenic stroke and recommend performing TEE [6]. Patients with the first episode of cerebrovascular accident can be treated with antiplatelets, with some authors advocating aspirin alone [7,8] and others advocating dual antiplatelet agents [6,9]. In our case, we used aspirin monotherapy, as this was his first episode of stroke. The recommendation of whether to use anticoagulation versus antiplatelet in patients with a single embolic event is unclear [10,11]. If there is a recurrence of the ischemic events while on antiplatelet therapy, the addition of anticoagulation therapy with warfarin should be considered before proceeding with surgical intervention [6]. It has a recurrence rate of around 30% [1] CVA after the second episode of a thromboembolic event. Hence, it is reasonable to offer surgical intervention with shared decision-making with the patient [12].


We recommend LE be considered in the differential diagnosis of embolic stroke. Patients with a first stroke episode can be treated conservatively with antiplatelet therapy. Shared decision-making about anticoagulation and surgical excision should be done in patients with recurrent ischemic events. In patients with poor or doubtful compliance with medication, surgery can be considered as the primary treatment.


1.. Kariyanna PT, Jayarangaiah A, Rednam C, Lambl’s excrescences and stroke: A scoping study: Int J Clin Res Trials, 2018; 3(2); 127

2.. Ornello R, Degan D, Tiseo C, Distribution and temporal trends from 1993 to 2015 of ischemic stroke subtypes: A systematic review and meta-analysis: Stroke, 2018; 49(4); 814-19

3.. Roldan CA, Shively BK, Crawford MH, Valve excrescences: Prevalence, evolution and risk for cardioembolism: J Am Coll Cardiol, 1997; 30(5); 1308-14

4.. Ammannaya GKK, Lambl’s excrescences: Current diagnosis and management: Cardiol Res, 2019; 10(4); 207-10

5.. Leitman M, Tyomkin V, Peleg E, Clinical significance and prevalence of valvular strands during routine echo examinations: Eur Heart J Cardiovasc Imaging, 2014; 15(11); 1226-30

6.. Chu A, Aung TT, Sahalon H, Lambl’s excrescence associated with cryptogenic stroke: A case report and literature review: Am J Case Rep, 2015; 16; 876-81

7.. Davogustto G, Fernando RR, Loghin C, Lambl’s excrescence, migrainous headaches, and “tiger stripes”: Puzzling findings in one patient: Tex Heart Inst J, 2015; 42(1); 70-72

8.. Wolf RC, Spiess J, Huber R, [Lambl’s excrescence and cerebral ischemic insult]: Nervenarzt, 2006; 77(12); 1492-94 [in German]

9.. Ker J, The serpentine mitral valve and cerebral embolism: Cardiovasc Ultrasound, 2011; 9(1); 7

10.. Kalavakunta JK, Peddi P, Bantu V, Lambl’s excrescences: A rare cause of stroke: J Heart Valve Dis, 2010; 19(5); 669-70

11.. Kamran H, Patel N, Singh G, Lambl’s excrescences: A case report and review of the literature: Clin Case Rep Rev, 2016; 2(7); 486-88

12.. Chong-Lei R, Sheng-Li J, Rong W, Diagnosis and treatment of Lambl’s excrescence on the aortic valve: Heart Surg Forum, 2018; 21(3); E148-50

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923