Diagnostic Delays in Metastatic Amelanotic Melanoma Presenting as Breast Pain

05 August 2020: Articles

Challenging differential diagnosis, Rare disease

Tiffanie Do ^E , Raisa Epistola ^E , Duong T. Hua ^E* , Maria M. Taylor ^B , Rose Venegas ^B

DOI: 10.12659/AJCR.921360

Am J Case Rep 2020; 21:e921360

Table 1. Review of patients with amelanotic melanoma involving the breast.

Article	Age, gender	Time to diagnosis	Method for diagnosis	Sites of involvement	Skin lesions	Receptors	Treatment outcome
Roy S. et al. (2008) []¹³	40 yr, Female	3 months of symptoms. Diagnosed on presentation	Simple mastectomy	Right breast mass	None	(+) S100 (+) HMB-45	No treatment aspatient was lost to follow up
Biswas A. et al. (2014) []¹⁴	32 yr, Female	18 months of symptoms after a lumpectomy. Diagnosed on presentation	Fine needle aspiration	Left breast mass; left axillary node	None	(+) S100 (+) HMB-45	Wide local excision of the left breast mass; left axillary node dissection; post-operative radiation therapy to the entire left breast; adjuvant immunotherapy with interferon alpha-2b; complete remission nine months after immunotherapy
Sathiah P. et al. (2017) []¹⁵	58 yr, Female	No timing of symptoms noted. Diagnosed at presentation	Core needle biopsy	Left breast mass; bilateral axillary nodes; bilateral cervical nodes; pericardial effusion	None	(+) S100 (+) HMB-45	No treatment as patient was lost to follow up
Kobayashi G. et al. (2000) []¹⁶	47 yr Female	3 weeks of symptoms. Diagnosed at presentation	Fine needle aspiration Skin biopsy	Right breast mass; right axillary node; back with nodular, pigmented ulcer	3×3 cm nodular hyperpigmented ulcer on the back	(+) S100 (+) HMB-45	No mention of treatment or follow up