05 August 2020
: Case report 
Diagnostic Delays in Metastatic Amelanotic Melanoma Presenting as Breast Pain
Challenging differential diagnosis, Rare disease
Tiffanie Do1EF, Raisa Epistola1EF, Duong T. Hua1EF*, Maria M. Taylor2BC, Rose Venegas2BCDOI: 10.12659/AJCR.921360
Am J Case Rep 2020; 21:e921360
Table 1. Review of patients with amelanotic melanoma involving the breast.
| Article | Age, gender | Time to diagnosis | Method for diagnosis | Sites of involvement | Skin lesions | Receptors | Treatment outcome |
|---|---|---|---|---|---|---|---|
| Roy S. et al. (2008) []13 | 40 yr, Female | 3 months of symptoms. Diagnosed on presentation | Simple mastectomy | Right breast mass | None | (+) S100 (+) HMB-45 | No treatment aspatient was lost to follow up |
| Biswas A. et al. (2014) []14 | 32 yr, Female | 18 months of symptoms after a lumpectomy. Diagnosed on presentation | Fine needle aspiration | Left breast mass; left axillary node | None | (+) S100 (+) HMB-45 | Wide local excision of the left breast mass; left axillary node dissection; post-operative radiation therapy to the entire left breast; adjuvant immunotherapy with interferon alpha-2b; complete remission nine months after immunotherapy |
| Sathiah P. et al. (2017) []15 | 58 yr, Female | No timing of symptoms noted. Diagnosed at presentation | Core needle biopsy | Left breast mass; bilateral axillary nodes; bilateral cervical nodes; pericardial effusion | None | (+) S100 (+) HMB-45 | No treatment as patient was lost to follow up |
| Kobayashi G. et al. (2000) []16 | 47 yr Female | 3 weeks of symptoms. Diagnosed at presentation | Fine needle aspiration Skin biopsy | Right breast mass; right axillary node; back with nodular, pigmented ulcer | 3×3 cm nodular hyperpigmented ulcer on the back | (+) S100 (+) HMB-45 | No mention of treatment or follow up |