Nesidioblastosis Associated with Pancreatic Heterotopia as a Differential Diagnosis of Hypoglycemia: A Literature Review and Case Report

06 July 2020: Articles

Challenging differential diagnosis, Rare coexistence of disease or pathology

Aline A. Lopes ^A* , Ana C. Miranda ^B , Marcelo S. Maior ^B , Roberto V. de Mello ^B , Francisco Bandeira ^A

DOI: 10.12659/AJCR.922778

Am J Case Rep 2020; 21:e922778

Table 2. Main characteristics of the selected reports.

Authors and year	Age and gender	Clinical presentation	Imaging and surgery aspects	Treatment
Kang H.: The Journal of Gastroenterology. 2014 []¹⁴	Female, 35 years old	Recurrent acute pancreatitis	Glucagon-positive 17 mm pancreatic tail neuroendocrine tumor with areas of nesidioblastosis in ectopic localization of pancreatic islets in central acinar areas	Distal pancreatectomy
Yasoshima H.: Pathology International. 2001 []¹⁵	Female, 5 months	Dyspnea, abdominal distension and hematemesis 30 hours after birth	Autopsy with jejunum nodule measuring 30×20×20 mm, corresponding to ectopic pancreatic tissue with topic and ectopic pancreas nesidioblastosis	Intensive care support with hypertonic glucose infusion
Schier F.: Pediatric Surgery International. 2000 []¹⁶	Child (undefined gender), 30 months	Severe hypoglycemia	Meckel’s diverticulum enlarged, measuring 45 mm. Presence of gastric and pancreatic tissue in Meckel’s diverticulum, with areas of nesidioblastosis in pancreatic tissue in Meckel’s diverticulum	Meckel’s diverticulum resection
Seki S.: Pediatrics International. 1990 []¹⁷	Newborn (undefined gender), 6 hours of life	Severe hypoglycemia, seizures and cyanosis	Laparotomy with normal pancreas. Tumor finding in the duodenum anterior wall, measuring 8×5×5 mm, corresponding to ectopic pancreatic tissue with areas of nesidioblastosis	Resection of tumor in duodenum and 75% of pancreas