30 June 2020
: Case report 
A Surviving Case of Acanthamoeba Granulomatous Amebic Encephalitis in a Hematopoietic Stem Cell Transplant Recipient
Challenging differential diagnosis, Unusual or unexpected effect of treatment
Niamh A. Keane1DEF*, Louise Marie Lane2C, Emma Canniff3BC, Daniel Hare4D, Simon Doran3BD, Eugene Wallace5E, Siobhan Hutchinson6B, Marie-Louise Healy7E, Brian Hennessy8BC, Jim Meaney3D, Peter Chiodini9D, Brian O’Connell4D, Alan Beausang2CD, Elisabeth Vandenberghe1EFDOI: 10.12659/AJCR.923219
Am J Case Rep 2020; 21:e923219
Table 1. Cerebrospinal fluid (CSF) analysis.
| Parameter | Result | |
|---|---|---|
| Peripheral blood | White cell count (cells/mm) | 2.3 |
| Neutrophils (cells/mm/%) | 2/87% | |
| Lymphocytes (cells/mm/%) | <0.1/4% | |
| Glucose (mg/dL) | 162 | |
| Protein (g/dL) | 5 | |
| Cerebrospinal fluid | White cell count (cells/mm) | 42 |
| Neutrophils (cells/mm/%) | 1/3% | |
| Lymphocytes (cells/mm/%) | 37/88% | |
| CD8 (cells/mm/%) | 32/88% | |
| CD4 (cells/mm/%) | 2/6% | |
| NK (cells/mm/%) | 3/7% | |
| Glucose (mg/dL) | 72 | |
| Protein (mg/dL) | 149 | |
| Microbiology CSF results | Bacterial culture | Negative |
| TB GeneXpert | Negative | |
| Viral PCR | Negative | |
| PCR | Negative | |
| Microsporidia PCR | Negative | |
| PCR for Acanthamoeba, Balamuthia, Naegleria | Negative | |
| * PCR of CSF for HSV1, HSV2, EBV, CMV, VZV, JCV, HHV6 and enterovirus were all negative. | ||