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25 June 2020: Articles

Cirrhosis in a Young Child Due to Fatty Liver; Importance of Early Screening: A Case Report and Review of the Literature

Challenging differential diagnosis, Rare disease

Hamza Hassan Khan A* , Christine E. Klingert B , Sanjay Kumar A , Hernando Lyons A

DOI: 10.12659/AJCR.923250

Am J Case Rep 2020; 21:e923250

Table 1. Reported cases of NASH developing to liver cirrhosis in childhood.

AuthorsYearPatient agePresentationLaboratory findingsHisto-pathological findingsMiscellaneous
BMI (kg/m2)Clinical presentationSGPT (IU/L)SGOT (IU/L)TriglyceridesHepatitis panel
Molleston et al. []10 20021032Patient presented with mildright upper-quadrant tenderness and fatigue367285Negative for Hepatitis A, B, and CNeedle liver biopsy: cirrhosisProminent spleen on abdominal ultrasound
Molleston et al. []10 20021337.9Presented with weight gain and palpable hepatomegaly8866Negative for Hepatitis A, B, and CNeedle liver biopsy: well-established, inactive cirrhosisHepatomegaly with steatosis on ultrasound Developed variceal bleeding, mild encephalopathy, and ascites at age 14
A-Kader et al. []7 20089ElevatedCirrhosis
A-Kader et al. []7 20089Increase from 27.5 to 31.2Presented with significant weight gain: BMI from 27.5 → 31.2 in 25 monthsElevatedProgression from stage 1 fibrosis to cirrhosis
Feldstein et al. []5 20091126.9Biopsy done due to persistently elevated liver enzymes Grade 3 esophageal varicesHyper-triglyceridemia hyper-cholesterolemiaLiver trans-plantation at age 20 due to end-stage liver disease and hepatopulmonary syndrome – Recurrent NASH at 9 months post-transplant
Feldstein et al. []5 20091833.6Presented with low HDL cholesterol and hypoxemia from hepato-pulmonary syndromeCirrhotic stage NASH Macro-vesicular steatosis 14 days post-transplantRequired liver transplant at age 25

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923