15 July 2020
: Case report 
Tigecycline-Induced Severe Hypoglycemia in a Non-Diabetic Individual: A Case Report and Brief Review of Tigecycline-Induced Severe Hypoglycemia
Unusual or unexpected effect of treatment, Unexpected drug reaction
Avik Ray1ABCDEF*, Swati Sharma1ABDEF, Shubham Atal1DEF, Balakrishnan Sadasivam1DEF, Ratinder Jhaj1EFDOI: 10.12659/AJCR.924556
Am J Case Rep 2020; 21:e924556
Table 1. The patient’s score for the Naranjo algorithm for adverse drug reaction causality assessment. Total score categories are defined as follows: Adverse Drug Reaction (ADR) is: definite ≥9; probable 5–8; possible 1–4; doubtful 0.
| S. No. | Question | Yes | No | Do not know | Score |
|---|---|---|---|---|---|
| 1. | Are there previous conclusive reports on this reaction? | +1 | 0 | 0 | +1 |
| 2. | Did the adverse event appear after the suspected drug was administered? | +2 | −1 | 0 | +2 |
| 3. | Did the adverse reaction improve when the drug was discontinued or a specific antagonist was administered? | +1 | 0 | 0 | +1 |
| 4. | Did the adverse reaction reappear when the drug was re-administered? | +2 | –1 | 0 | +2 |
| 5. | Are there alternative causes (other than the drug) that could solely have caused the reaction? | −1 | +2 | 0 | +2 |
| 6. | Did the reaction reappear when a placebo was given? | −1 | +1 | 0 | 0 |
| 6. | Was the drug detected in the blood (or other fluids) in a concentration known to be toxic? | +1 | 0 | 0 | 0 |
| 7. | Was the reaction more severe when the dose was increased, or less severe when the dose was decreased? | +1 | 0 | 0 | 0 |
| 8. | Did the patient have a similar reaction to the same or similar drugs in any previous exposure? | +1 | 0 | 0 | 0 |
| 9. | Was the adverse event confirmed by objective evidence? | +1 | 0 | 0 | +1 |