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15 July 2020 : Case report  India

Tigecycline-Induced Severe Hypoglycemia in a Non-Diabetic Individual: A Case Report and Brief Review of Tigecycline-Induced Severe Hypoglycemia

Unusual or unexpected effect of treatment, Unexpected drug reaction

Avik Ray1ABCDEF*, Swati Sharma1ABDEF, Shubham Atal1DEF, Balakrishnan Sadasivam1DEF, Ratinder Jhaj1EF

DOI: 10.12659/AJCR.924556

Am J Case Rep 2020; 21:e924556

Table 1. The patient’s score for the Naranjo algorithm for adverse drug reaction causality assessment. Total score categories are defined as follows: Adverse Drug Reaction (ADR) is: definite ≥9; probable 5–8; possible 1–4; doubtful 0.

S. No.QuestionYesNoDo not knowScore
1.Are there previous conclusive reports on this reaction?+100+1
2.Did the adverse event appear after the suspected drug was administered?+2−10+2
3.Did the adverse reaction improve when the drug was discontinued or a specific antagonist was administered?+100+1
4.Did the adverse reaction reappear when the drug was re-administered?+2–10+2
5.Are there alternative causes (other than the drug) that could solely have caused the reaction?−1+20+2
6.Did the reaction reappear when a placebo was given?−1+100
6.Was the drug detected in the blood (or other fluids) in a concentration known to be toxic?+1000
7.Was the reaction more severe when the dose was increased, or less severe when the dose was decreased?+1000
8.Did the patient have a similar reaction to the same or similar drugs in any previous exposure?+1000
9.Was the adverse event confirmed by objective evidence?+100+1

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923