Suspected Levetiracetam-Induced Rhabdomyolysis: A Case Report and Literature Review

28 October 2020: Articles

Unusual or unexpected effect of treatment, Unexpected drug reaction

Imran A. Moinuddin ^B*

DOI: 10.12659/AJCR.926064

Am J Case Rep 2020; 21:e926064

Table 1. Data of reported cases of levetiracetam-induced rhabdomyolysis.

Reference	Year	Patient		Acute kidney injury	Myalgias	Peak CK (IU/L)	Time to peak CK
Reference	Year	Age (years)	Sex	Acute kidney injury	Myalgias	Peak CK (IU/L)	Time to peak CK
Thomas et al. []¹²	2019	62	M	No	No	19 000	5 days
Rastogi et al. []¹³	2018	42	M	Yes	Unknown	30 000	3 days
Mena-Martin et al. []²⁰	2018	28	M	Yes	No	1559	7 days
Kubota et al. []²¹	2017	26	F	No	Yes	4396	15 days
Sohn et al. []²²	2017	40	M	No	Yes	7800	6 days
Di Lorenzo and Li []¹⁴	2017	27	M	NR	No	49 539	5 days
Shahbaz et al. []²³	2016	43	M	No	No	29 750	7 days
Singh et al. []¹⁵	2016	16	M	Yes	Yes	15 111	4 days
Ramon et al. []¹⁶	2016	25	M	No	Unknown	15 811	4 days
Sivasambu and Yogarajah []¹⁷	2015	30	M	NR	No	37 622	4 days
Akiyama et al. []⁶	2014	29	F	NR	Yes	2410	4 days
Isaacson et al. []²⁴	2014	19	M	Yes	No	29 136	8 days
Spengler et al. []¹⁸	2014	23	F	Yes	Yes	1368	4 days
NR – not reported; CK – creatine kinase.