18 August 2020
: Case report 
A 31-Year-Old Man with COVID-19-Associated Empyema and Lupus Anticoagulant
Unknown etiology, Unusual clinical course, Challenging differential diagnosis, Diagnostic / therapeutic accidents, Unusual setting of medical care
Keerthi Yarlagadda1ABCDEF*, Kaihong Mi2ACDEF, Selin Sendil1EF, Connie L. Koons3E, Saketram Komanduri1EF, John T. Cinicola1ADOI: 10.12659/AJCR.926623
Am J Case Rep 2020; 21:e926623
Table 1. Results of hematology workup.
| Parameter | Value | Reference range |
|---|---|---|
| Prothrombin time (PT) | 27.7 seconds | 9.4–12.5 |
| International Normalized Ratio | 2.4 | 0.8–1.1 |
| Activated Partial Thromboplastin Time (APTT) | 47.2 seconds | 25.1–36.5 |
| PTT LA (Partial Thromboplastin Time Lupus Anticoagulant) mixing | 75 seconds | ≤40 |
| Immediate PTT-LA mix | Not corrected | |
| Immediate PT mix | 10.8 seconds | ≤11.5 |
| Platelet count | 420 K/uL | 140–366 |
| D-dimer | 2590 FFEU/mL | 0–499 |
| Fibrinogen | 590 MG/DL | 200–393 |
| Factor VII | 45 | 60–150% |
| Factor VIII | 302 | 50–180% |
| Factor XII | 48 | 50–150% |
| B2- Glycoprotein I IgG Ab | <9 | ≤20 SGU |
| B2- Glycoprotein I IgM Ab | <9 | ≤20 SMU |
| B2-Glycoprotein I IgA Ab | <9 | ≤20 SAU |
| Lupus Anticoagulant | Detected | |
| Anti-Cardiolipin IgG | <14 | ≤14 GPL |
| Anti-Cardiolipin IgM | 45 | ≤12 MPL |
| Anti-Nuclear Antibody | Negative |