07 March 2021
: Case report 
Kikuchi-Fujimoto Disease: Report of a Case with Progression to Lupus Nephritis
Challenging differential diagnosis, Rare coexistence of disease or pathology
Jorge Hurtado-Díaz1B, María Lucero Espinoza-Sánchez1C, Eduardo Rojas-Milán1D, Erik Cimé-Aké1E, María de los Ángeles Macias2G, Lizeth Romero-Ibarra3F, Olga Lidia Vera-Lastra14F*DOI: 10.12659/AJCR.927351
Am J Case Rep 2021; 22:e927351
Table 1. Evolution of laboratory finding. On admission, discharge after 1 month, 2 months and 1 year of evolution.
| On admission | Discharge after 1 month | After 2 months | After 1 year | |
|---|---|---|---|---|
| Hemoglobin g/dL | 4.7 | 8.0 | 7.6 | 13.1 |
| Leukocytes 10/L | 1.900 | 6.000 | 4.500 | 5.100 |
| Lymphocytes 10/L | 1000 | 1000 | 500 | 1630 |
| Platelets 10/L | 63 000 | 144 000 | 116 000 | 307 000 |
| Proteinuria in Urine g/dl 24 h | Normal | <0.68 mg/24 h | 14 g/24 h | 140 mg/24 h |
| Leucocyturia HPF | 6–8 per HPF | 1–2 per HPF | Uncontainable | 0–1 per HPF |
| Erythrocyturia HPF | Uncontainable | 1–2 per HPF | Uncontainable | Negative |
| Cilindruria | Abundant | – | Abundant | Negative |
| Proteinuria total mg/dl | 100 mg/dl | 30 mg/dl | >500 mg/dl | Negative |
| Serum proteins g/dl | 3.90 | 6.20 | 4.2 | 6.4 |
| Albumin g/dl | 1.60 | 3.80 | 3.0 | 4.1 |
| Creatinine mg/dl | 1.03 | 0.40 | 1.10 | 0.54 |
| Total bilirubin mg/dl | 1.93 | 0.67 | 0.35 | 0.40 |
| Direct bilirubin mg/dl | 1.05 | 0.11 | 0.19 | 0.24 |
| Indirect bilirubin mg/dl | 0.88 | 0.56 | 0.16 | 0.16 |
| AST U/L | 898 | 43 | 16 | 68.1 |
| ALT U/L | 168 | 15 | 44 | 105.5 |
| Alkaline phosphatase UI/L | 542 | 59 | – | 110 |
| Lactate dehydrogenase UI/L | 1024 | 146 | 316 | 220 |
| PCR mg/L | 30.5 | – | – | 5.55 |
| Coombs direct/indirect | Negative | – | – | – |
| Rheumatoid factor UI/ml | Negative | – | – | <11.4 |
| C3 mg/dl NLV: 80–200 mg/dl | 10 | – | 29 | 105 |
| C4 mg/dl NLV: 10–50 mg/dl | <2 | – | 6 | 12 |
| ANA NLV: Negative <1: 80 | 1: 80 Speckled fine pattern | – | 1: 80 Speckled fine pattern | 1: 160 Speckled fine Pattern |
| Anti-dsDNA U/mL NLV: Negative <200 UI/ml | Negative | – | Positive | Positive |
| Lupus anticoagulant | – | – | Negative | – |
| Anticardiolipin Ig G U | – | – | Negative | – |
| Anticardiolipin Ig M U | – | – | Negative | – |
| NLV – normal laboratory values; HPF – high-power field; ANA – anti-nuclear antibodies; Anti-dsDNA – anti-double-stranded deoxyribonucleic acid antibodies. | ||||