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07 March 2021: Articles

Kikuchi-Fujimoto Disease: Report of a Case with Progression to Lupus Nephritis

Challenging differential diagnosis, Rare coexistence of disease or pathology

Jorge Hurtado-Díaz B , María Lucero Espinoza-Sánchez C , Eduardo Rojas-Milán D , Erik Cimé-Aké E , María de los Ángeles Macias G , Lizeth Romero-Ibarra F , Olga Lidia Vera-Lastra F*

DOI: 10.12659/AJCR.927351

Am J Case Rep 2021; 22:e927351

Table 2. Comparison among clinical, laboratory, and histological findings in SLE and KFD.

SLE (frequency)KFD (frequency)
Cervical lymphadenopathies40%50–98%
Generalized lymphadenitis10%1–22%
Body weight loss83%10–51%
Skin lesion53–78%10–40%
Low complement47–55%21–27%
MicroscopicFollicular hyperplasia, scattered immunoblasts, and plasma cells with increased vascularity with Azzopardi phenomenonIrregular paracortical areas of coagulative necrosis with abundant karyorrhectic debris, and abundance of histiocytes at the margin of the necrotic area
ImmunohistochemistryCD4+ with predominance of CD8+ T lymphocytesCD8+ T lymphocytes myeloperoxidase+ CD68 and CD 123+
SLE – systemic lupus erythematosus; KFD – Kikuchi-Fujimoto disease; ANA – anti-nuclear antibodies; Anti-dsDNA – anti-double-stranded deoxyribonucleic acid antibodies.

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923