07 March 2021
: Case report 
Kikuchi-Fujimoto Disease: Report of a Case with Progression to Lupus Nephritis
Challenging differential diagnosis, Rare coexistence of disease or pathology
Jorge Hurtado-Díaz1B, María Lucero Espinoza-Sánchez1C, Eduardo Rojas-Milán1D, Erik Cimé-Aké1E, María de los Ángeles Macias2G, Lizeth Romero-Ibarra3F, Olga Lidia Vera-Lastra14F*DOI: 10.12659/AJCR.927351
Am J Case Rep 2021; 22:e927351
Table 2. Comparison among clinical, laboratory, and histological findings in SLE and KFD.
| SLE (frequency) | KFD (frequency) | |
|---|---|---|
| Cervical lymphadenopathies | 40% | 50–98% |
| Generalized lymphadenitis | 10% | 1–22% |
| Fever | 52% | 30–67% |
| Body weight loss | 83% | 10–51% |
| Hepato-splenomegaly | 10–45% | 1–22% |
| Arthralgia/arthritis | 60%/20% | 5–34% |
| Headache | 25–80% | 17–33% |
| Diarrhea | Rare | Rare |
| Skin lesion | 53–78% | 10–40% |
| Anemia | 60–70% | 28–54% |
| Leucopenia/lymphopenia | 30–40% | 25–58% |
| Thrombocytopenia | 25–50% | 5% |
| ANA | 70–98% | 8–45% |
| Anti-DNA | 70% | 7–18% |
| Low complement | 47–55% | 21–27% |
| Microscopic | Follicular hyperplasia, scattered immunoblasts, and plasma cells with increased vascularity with Azzopardi phenomenon | Irregular paracortical areas of coagulative necrosis with abundant karyorrhectic debris, and abundance of histiocytes at the margin of the necrotic area |
| Immunohistochemistry | CD4+ with predominance of CD8+ T lymphocytes | CD8+ T lymphocytes myeloperoxidase+ CD68 and CD 123+ |
| SLE – systemic lupus erythematosus; KFD – Kikuchi-Fujimoto disease; ANA – anti-nuclear antibodies; Anti-dsDNA – anti-double-stranded deoxyribonucleic acid antibodies. | ||