16 January 2021: Articles
Pancreatic Gastrinoma, Gastrointestinal Stromal Tumor (GIST), Pheochromocytoma, and Hürthle Cell Neoplasm in a Patient with Neurofibromatosis Type 1: A Case Report and Literature Review
Rare coexistence of disease or pathology
Arif A. Arif A , Peter T.W. Kim A , Adrienne Melck A , Andrew Churg A , Zachary Schwartz A , Heather C. Stuart A*DOI: 10.12659/AJCR.927761
Am J Case Rep 2021; 22:e927761
Table 1. Pancreatic neoplasms in patients with NF1.
| Authors [ref.] | Presenting symptom | Year | Age (years)/Sex | Site of tumor in pancreas | Tumor type | Size |
|---|---|---|---|---|---|---|
| Coskey and Tranquanda []8 | Hypoglycemic seizures, weight gain | 1964 | 66/F | Body and tail | Insulinoma | 20 mm |
| Knight et al. []9 | Unknown | 1973 | 73/M | unknown | Adenocarcinoma | n/a |
| Keller and Logan []10 | Pancreatitis | 1977 | 27/F | Head | Adenocarcinoma | n/a |
| Niv et al. []11 | Obstructive jaundice | 1987 | 47/M | Head | Adenocarcinoma | n/a |
| Saurenmann et al. []12 | Unknown | 1987 | 62/M | Head | Somatostatinoma | n/a |
| Swinburn et al. []13 | Vomiting, obstruction | 1988 | 62/M | Head | Somatostatinoma | n/a |
| Walsh and Brandspigel []14 | GI bleeding, abdominal pain, anemia | 1989 | 35/F | Head | Schwannoma | n/a |
| Coombs []15 | GI bleeding, anemia | 1990 | 74/F | Head | Schwannoma | 35 mm |
| Sood et al. []16 | unknown | 1991 | ?/? | unknown | Cystadenoma | n/a |
| Fung and Lam []17 | Hypoglycemic seizures | 1995 | 45/M | Body | Insulinoma | n/a |
| Yamamoto et al. []18 | Abdominal Pain | 1996 | 44/M | Body and tail | Adenocarcinoma | 70 mm |
| Kretzschmar et al. []19 | Unknown | 2001 | 58/? | Tail | Cystadenoma | 58 mm |
| Thannberger et al. []20 | Abdominal Pain | 2001 | 28/M | Unknown | Somatostatinoma | n/a |
| Fujisawa et al. []21 | Abdominal pain and weight loss | 2002 | 66/F | Head | Non-functional NET | 20 mm |
| Perren et al. []22 | Weakness, sweating | 2006 | ?/? | Pancreas, NOS* | Insulinoma | n/a |
| Barahona-Garrido et al. []23 | Anemia | 2009 | 47/F | Ectopic | Somatostatinoma | n/a |
| Takai et al. []24 | Weight loss and anorexia | 2009 | 48/M | Head | Somatostatinoma | 20 mm |
| Bukkems et al. []25 | Jaundice, diarrhea | 2010 | 48/M | Head | Somatostatinoma | 35 mm |
| Wilsher []26 | Abdominal pain | 2011 | 52/F | Body | Cystadenoma | 16 mm |
| Majumder et.al. []27 | Abdominal pain, hypertension | 2012 | 34/F | Head | Pheochromocytoma-paraganglioma | 68 mm |
| Nishi et al. []28 | Liver dysfunction | 2012 | 62/M | Head | non-functional NET | 30 mm |
| Moletta et al. []29 | Abdominal pain, diarrhea | 2012 | 25/M | Head | Neuroendocrine tumor, NOS | 30 mm |
| Rogers et al. []30 | Hypoglycemic syncope | 2015 | 75/H | Body | Insulinoma | 15 mm |
| Xueye et al. []31 | Anemia | 2017 | 38/F | Head | Neuroendocrine tumor, NOS | 20 mm |
| Present study | Perforation, obstruction | 2020 | 67/F | Head | Gastrinoma | 37 mm |
| NOS – none other specified; NET – neuroendocrine tumor; n/a – not applicable. Search was conducted on MEDLINE, Cochrane and EMBASE from inception to May 2020. | ||||||