Pancreatic Gastrinoma, Gastrointestinal Stromal Tumor (GIST), Pheochromocytoma, and Hürthle Cell Neoplasm in a Patient with Neurofibromatosis Type 1: A Case Report and Literature Review

Arif A. Arif; Peter T.W. Kim; Adrienne Melck; Andrew Churg; Zachary Schwartz; Heather C. Stuart

doi:10.12659/AJCR.927761

16 January 2021 : Case report Canada

Pancreatic Gastrinoma, Gastrointestinal Stromal Tumor (GIST), Pheochromocytoma, and Hürthle Cell Neoplasm in a Patient with Neurofibromatosis Type 1: A Case Report and Literature Review

Rare coexistence of disease or pathology

Arif A. Arif^1ADEF, Peter T.W. Kim^2ABDE, Adrienne Melck^2ABDE, Andrew Churg^3ABDE, Zachary Schwartz^4ABDE, Heather C. Stuart^2ABDEFG*

DOI: 10.12659/AJCR.927761

Am J Case Rep 2021; 22:e927761

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Table 1. Pancreatic neoplasms in patients with NF1.

Authors [ref.]	Presenting symptom	Year	Age (years)/Sex	Site of tumor in pancreas	Tumor type	Size
Coskey and Tranquanda []⁸	Hypoglycemic seizures, weight gain	1964	66/F	Body and tail	Insulinoma	20 mm
Knight et al. []⁹	Unknown	1973	73/M	unknown	Adenocarcinoma	n/a
Keller and Logan []¹⁰	Pancreatitis	1977	27/F	Head	Adenocarcinoma	n/a
Niv et al. []¹¹	Obstructive jaundice	1987	47/M	Head	Adenocarcinoma	n/a
Saurenmann et al. []¹²	Unknown	1987	62/M	Head	Somatostatinoma	n/a
Swinburn et al. []¹³	Vomiting, obstruction	1988	62/M	Head	Somatostatinoma	n/a
Walsh and Brandspigel []¹⁴	GI bleeding, abdominal pain, anemia	1989	35/F	Head	Schwannoma	n/a
Coombs []¹⁵	GI bleeding, anemia	1990	74/F	Head	Schwannoma	35 mm
Sood et al. []¹⁶	unknown	1991	?/?	unknown	Cystadenoma	n/a
Fung and Lam []¹⁷	Hypoglycemic seizures	1995	45/M	Body	Insulinoma	n/a
Yamamoto et al. []¹⁸	Abdominal Pain	1996	44/M	Body and tail	Adenocarcinoma	70 mm
Kretzschmar et al. []¹⁹	Unknown	2001	58/?	Tail	Cystadenoma	58 mm
Thannberger et al. []²⁰	Abdominal Pain	2001	28/M	Unknown	Somatostatinoma	n/a
Fujisawa et al. []²¹	Abdominal pain and weight loss	2002	66/F	Head	Non-functional NET	20 mm
Perren et al. []²²	Weakness, sweating	2006	?/?	Pancreas, NOS*	Insulinoma	n/a
Barahona-Garrido et al. []²³	Anemia	2009	47/F	Ectopic	Somatostatinoma	n/a
Takai et al. []²⁴	Weight loss and anorexia	2009	48/M	Head	Somatostatinoma	20 mm
Bukkems et al. []²⁵	Jaundice, diarrhea	2010	48/M	Head	Somatostatinoma	35 mm
Wilsher []²⁶	Abdominal pain	2011	52/F	Body	Cystadenoma	16 mm
Majumder et.al. []²⁷	Abdominal pain, hypertension	2012	34/F	Head	Pheochromocytoma-paraganglioma	68 mm
Nishi et al. []²⁸	Liver dysfunction	2012	62/M	Head	non-functional NET	30 mm
Moletta et al. []²⁹	Abdominal pain, diarrhea	2012	25/M	Head	Neuroendocrine tumor, NOS	30 mm
Rogers et al. []³⁰	Hypoglycemic syncope	2015	75/H	Body	Insulinoma	15 mm
Xueye et al. []³¹	Anemia	2017	38/F	Head	Neuroendocrine tumor, NOS	20 mm
Present study	Perforation, obstruction	2020	67/F	Head	Gastrinoma	37 mm
NOS – none other specified; NET – neuroendocrine tumor; n/a – not applicable. Search was conducted on MEDLINE, Cochrane and EMBASE from inception to May 2020.

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Pancreatic Gastrinoma, Gastrointestinal Stromal Tumor (GIST), Pheochromocytoma, and Hürthle Cell Neoplasm in a Patient with Neurofibromatosis Type 1: A Case Report and Literature Review

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