Pancreatic Gastrinoma, Gastrointestinal Stromal Tumor (GIST), Pheochromocytoma, and Hürthle Cell Neoplasm in a Patient with Neurofibromatosis Type 1: A Case Report and Literature Review

16 January 2021: Articles

Rare coexistence of disease or pathology

Arif A. Arif ^A , Peter T.W. Kim ^A , Adrienne Melck ^A , Andrew Churg ^A , Zachary Schwartz ^A , Heather C. Stuart ^A*

DOI: 10.12659/AJCR.927761

Am J Case Rep 2021; 22:e927761

Table 2. Presenting symptoms in NF-1 patients with gastrinomas.

Authors [ref.]	Presenting symptom	Year	Age (yrs)/Sex	Site of tumor	Size
Garcia et al. []³⁵	Vomiting, epigastric pain, hematemesis, ulcers	1976	13/M	Lesser curvature of stomach	6 mm
Chagnon et al. []³⁶	High acid section	1985	49/M	unknown	n/a
Lee et al. []³⁷	Epigastric soreness, heartburn	2005	41/F	Duodenal wall	25 mm
Alshikho et al. []³⁸	Epigastric soreness, heartburn, vomiting	2016	28/F	Duodenal wall	26 mm
Present study	Perforation, obstruction	2020	67/F	Head of pancreas	37 mm
n/a – not applicable. Search was conducted on MEDLINE, Cochrane and EMBASE from inception to May 2020.