24 February 2021
: Case report 
Complicated Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome History in a 14-Year-Old
Unknown etiology, Challenging differential diagnosis, Diagnostic / therapeutic accidents, Unexpected drug reaction
Michael Tomani1ADEF*, Cristina Caridi1ABEF, Oksana Tatarina-Nulman1ABEF, Cascya Charlot1ADEF, Pramod Narula1ADEFDOI: 10.12659/AJCR.927951
Am J Case Rep 2021; 22:e927951
Table 3. Drug-induced hypersensitivity syndrome (DIHS)30 criteria.
| 1. | Maculopapular rash developing >3 weeks after starting with the suspected drug |
| 2. | Prolonged clinical symptoms 2 weeks after discontinuation of the suspected drug |
| 3. | Fever >38.0 |
| 4. | Liver abnormalities (alanine aminotransferase >100 U/L) |
| 5. | Leukocyte abnormalities |
| 6. | Leukocytosis (>11×10/L) |
| 7. | Atypical lymphocytosis (>5%) |
| 8. | Eosinophilia (>1.5×10/L) |
| 9. | Lymphadenopathy |
| 10. | Human Herpes 6 reactivation |