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04 May 2021: Articles

Rare Mixed Adenoneuroendocrine Carcinoma of the Gallbladder: Case Report and Review of Literature

Rare disease

Adriano C. Costa A , Camilla L.C. Cavalcanti B , Henrique G.B. Coelho B* , Luís Henrique A. Leão C , Daniel Tenório Camelo Soares B , Fernando Santa-Cruz C , Alexandre R. Paz B , Álvaro A.B. Ferraz A

DOI: 10.12659/AJCR.929511

Am J Case Rep 2021; 22:e929511

Table 1. Previous reported cases of mixed adenoneuroendocrine carcinoma of the gallbladder.

AuthorAgeSexPrimary symptomsStageCgASynATreatmentOutcomes
Our case68FRUQ painIIIb++RC+Radiotherapy+5-FURetroperitoneal metastasis 6 months after surgery
Yannakou, 2001 []7 72FEpigastric pain, nausea, weight lossN/ARCDied 2 months after the surgery
Shimizu, 2006 []1 58MEpigastric painIVa+N/ARight hepatic trisegmentectomyTumor recurrence 3 months after surgery. Died 4 months after surgery
Oshiro, 2008 []8 55FBack pain, fever, epigastric painIIIa++Pancreaticoduodenectomy, gallbladder, bile duct, and liverAlive without signs of recurrence 20 months after surgery
Sato, 2010 []16 68FAsymptomaticN/A++RC, 4 and 5 liver segmentectomyAlive without signs of recurrence 12 months after surgery
Mondolfi, 2011 []18 48FRUQ painN/A++Extended left lobectomy, partial right hepatectomySurgery was successful and the patient recovered without complications
Song, 2012 []24 55FEpigastric painIIIa++RC and lymph node dissection in hepatoduodenal ligament and common hepatic artery+SST+NACT: Carboplatin, VP16, Paclitaxel+OctreotideAlive without signs of recurrence 7 months after surgery
Abe, 2013 []14 81FAsymptomaticN/A++RCAlive without signs of recurrence 4 years after surgery
Shintaku, 2013 []9 80MAsymptomaticN/A++RCAlive without signs of recurrence 8 months after surgery
Chatterjee, 2014 []17 73FAsymptomaticI++RC+External beam radiotherapy with 5-FU11 months after surgery, a metastatic nodule on the anterior abdominal wall was detected
Chen, 2014 []10 34MRUQ painN/A++RC and radical lymph node dissection (adjuvant chemotherapy was refused)Alive with lymph node enlargement in the retroperitoneum and hepatic hilum at 4 months after surgery
Meguro, 2014 []15 54FEpigastric painII++RC, Extrahepatic bile duct resection, lymph node dissection, and hepaticojejunostomyAlive without signs of recurrence 24 months after surgery
Acosta, 2015 []12 55FEpigastric and RUQ painN/A++Robotic-assisted LC and Revision surgeryA second surgery was scheduled to complete an oncologically adequateprocedure
Azad, 2015 []11 62FAsymptomaticN/AN/A+RCAlive and asymptomatic 2 years after surgery
Kanetkar, 2018 []19 77FN/AIIIbN/AN/ARC+NACT: 3 cycles of carboplatin-etoposide6 months follow-up after surgery. 6 months without signs of recurrence
63FAsymptomaticIIN/AN/ARevision RC+ACT: 6 cycles of carboplatin-etoposide3 months follow-up after surgery. 3 months without signs of recurrence
50MN/AIIN/AN/ARevision RC+ACT: 6 cycles of carboplatin-etoposide3 months follow-up after surgery. 3 months without signs of recurrence
47FN/AIIIaN/AN/ARC22 months follow-up after surgery. 22 months without signs of recurrence
64FN/AIIIbN/AN/ARC7 months follow-up after surgery. 4 months without signs of recurrence
Lin, 2018 []20 43FRUQ painIIIa++RC, partial liver resection, radical lymph node dissection+SST+ACT: 6 cycles of cisplatin+etoposide +octreotideAlive 21 months after surgery
Parsa, 2018 []5 74FEpigastric and abdominal painN/A+_Laparoscopic cholecystectomy with a wedge resection of the liverN/A
76MRUQ pain, fever, jaundiceN/A++Open cholecystectomyN/A
Sciarra, 2019 []21 66FAbdominal painN/A++RC+hepatic resection of the vesicular bed+retro-duodenal lymph nodes resection+lymph nodes close to hepatic artery resectionAlive and asymptomatic 5 months after surgery
Kamei, 2020 []22 53FN/AIVb+Extended left hemihepatectomy with extrahepatic bile duct resection+NACT: gemcitabine and cisplatin for 12 months6 months after surgery, metastatic disease in the Morrison’s pouch was discovered. Died 27 months after the surgery
CgA – chromogranin A; SynA – synaptophysin A; F – Female; M – Male; RC – radical cholecystectomy; RUQ – right upper quadrant; N/A – not available; 5-FU – 5-Fluorouracil; SST – somatostatin; NACT – neoadjuvant chemotherapy; ACT – adjuvant chemotherapy.

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923