04 May 2021
: Case report 
Rare Mixed Adenoneuroendocrine Carcinoma of the Gallbladder: Case Report and Review of Literature
Rare disease
Adriano C. Costa12ADE, Camilla L.C. Cavalcanti3BCF, Henrique G.B. Coelho4BDEF*, Luís Henrique A. Leão4CEF, Daniel Tenório Camelo Soares4BEF, Fernando Santa-Cruz4CDE, Alexandre R. Paz5BCD, Álvaro A.B. Ferraz36AEFDOI: 10.12659/AJCR.929511
Am J Case Rep 2021; 22:e929511
Table 1. Previous reported cases of mixed adenoneuroendocrine carcinoma of the gallbladder.
| Author | Age | Sex | Primary symptoms | Stage | CgA | SynA | Treatment | Outcomes |
|---|---|---|---|---|---|---|---|---|
| Our case | 68 | F | RUQ pain | IIIb | + | + | RC+Radiotherapy+5-FU | Retroperitoneal metastasis 6 months after surgery |
| Yannakou, 2001 []7 | 72 | F | Epigastric pain, nausea, weight loss | N/A | – | – | RC | Died 2 months after the surgery |
| Shimizu, 2006 []1 | 58 | M | Epigastric pain | IVa | + | N/A | Right hepatic trisegmentectomy | Tumor recurrence 3 months after surgery. Died 4 months after surgery |
| Oshiro, 2008 []8 | 55 | F | Back pain, fever, epigastric pain | IIIa | + | + | Pancreaticoduodenectomy, gallbladder, bile duct, and liver | Alive without signs of recurrence 20 months after surgery |
| Sato, 2010 []16 | 68 | F | Asymptomatic | N/A | + | + | RC, 4 and 5 liver segmentectomy | Alive without signs of recurrence 12 months after surgery |
| Mondolfi, 2011 []18 | 48 | F | RUQ pain | N/A | + | + | Extended left lobectomy, partial right hepatectomy | Surgery was successful and the patient recovered without complications |
| Song, 2012 []24 | 55 | F | Epigastric pain | IIIa | + | + | RC and lymph node dissection in hepatoduodenal ligament and common hepatic artery+SST+NACT: Carboplatin, VP16, Paclitaxel+Octreotide | Alive without signs of recurrence 7 months after surgery |
| Abe, 2013 []14 | 81 | F | Asymptomatic | N/A | + | + | RC | Alive without signs of recurrence 4 years after surgery |
| Shintaku, 2013 []9 | 80 | M | Asymptomatic | N/A | + | + | RC | Alive without signs of recurrence 8 months after surgery |
| Chatterjee, 2014 []17 | 73 | F | Asymptomatic | I | + | + | RC+External beam radiotherapy with 5-FU | 11 months after surgery, a metastatic nodule on the anterior abdominal wall was detected |
| Chen, 2014 []10 | 34 | M | RUQ pain | N/A | + | + | RC and radical lymph node dissection (adjuvant chemotherapy was refused) | Alive with lymph node enlargement in the retroperitoneum and hepatic hilum at 4 months after surgery |
| Meguro, 2014 []15 | 54 | F | Epigastric pain | II | + | + | RC, Extrahepatic bile duct resection, lymph node dissection, and hepaticojejunostomy | Alive without signs of recurrence 24 months after surgery |
| Acosta, 2015 []12 | 55 | F | Epigastric and RUQ pain | N/A | + | + | Robotic-assisted LC and Revision surgery | A second surgery was scheduled to complete an oncologically adequateprocedure |
| Azad, 2015 []11 | 62 | F | Asymptomatic | N/A | N/A | + | RC | Alive and asymptomatic 2 years after surgery |
| Kanetkar, 2018 []19 | 77 | F | N/A | IIIb | N/A | N/A | RC+NACT: 3 cycles of carboplatin-etoposide | 6 months follow-up after surgery. 6 months without signs of recurrence |
| 63 | F | Asymptomatic | II | N/A | N/A | Revision RC+ACT: 6 cycles of carboplatin-etoposide | 3 months follow-up after surgery. 3 months without signs of recurrence | |
| 50 | M | N/A | II | N/A | N/A | Revision RC+ACT: 6 cycles of carboplatin-etoposide | 3 months follow-up after surgery. 3 months without signs of recurrence | |
| 47 | F | N/A | IIIa | N/A | N/A | RC | 22 months follow-up after surgery. 22 months without signs of recurrence | |
| 64 | F | N/A | IIIb | N/A | N/A | RC | 7 months follow-up after surgery. 4 months without signs of recurrence | |
| Lin, 2018 []20 | 43 | F | RUQ pain | IIIa | + | + | RC, partial liver resection, radical lymph node dissection+SST+ACT: 6 cycles of cisplatin+etoposide +octreotide | Alive 21 months after surgery |
| Parsa, 2018 []5 | 74 | F | Epigastric and abdominal pain | N/A | + | _ | Laparoscopic cholecystectomy with a wedge resection of the liver | N/A |
| 76 | M | RUQ pain, fever, jaundice | N/A | + | + | Open cholecystectomy | N/A | |
| Sciarra, 2019 []21 | 66 | F | Abdominal pain | N/A | + | + | RC+hepatic resection of the vesicular bed+retro-duodenal lymph nodes resection+lymph nodes close to hepatic artery resection | Alive and asymptomatic 5 months after surgery |
| Kamei, 2020 []22 | 53 | F | N/A | IVb | – | + | Extended left hemihepatectomy with extrahepatic bile duct resection+NACT: gemcitabine and cisplatin for 12 months | 6 months after surgery, metastatic disease in the Morrison’s pouch was discovered. Died 27 months after the surgery |
| CgA – chromogranin A; SynA – synaptophysin A; F – Female; M – Male; RC – radical cholecystectomy; RUQ – right upper quadrant; N/A – not available; 5-FU – 5-Fluorouracil; SST – somatostatin; NACT – neoadjuvant chemotherapy; ACT – adjuvant chemotherapy. | ||||||||