Logo American Journal of Case Reports

Call: 1.631.629.4328
Mon-Fri 10 am - 2 pm EST

Contact Us

Logo American Journal of Case Reports Logo American Journal of Case Reports Logo American Journal of Case Reports

11 March 2021: Articles

A Woman with a 27-Year History of Hyperparathyroidism and Hypercalcemia Who Was Diagnosed with Low-Grade Parathyroid Carcinoma

Challenging differential diagnosis, Diagnostic / therapeutic accidents, Unusual setting of medical care, Rare disease, Educational Purpose (only if useful for a systematic review or synthesis)

Monika Kaszczewska A* , Michał Popow A , Witold Chudziński A , Joanna Kaszczewska B , Magdalena Bogdańska B , Joanna Podgórska B , Agnieszka Czarniecka B , Zbigniew Gałązka A

DOI: 10.12659/AJCR.930301

Am J Case Rep 2021; 22:e930301

Table 1. Summary of the important points in the diagnostic and treatment period.

1989–1992ESWL procedures due to symptomatic nephrolithiasis
1992Diagnosis of hypercalcemia secondary to primary hyperparathyroidism (adenoma of right lower parathyroid gland)
1993Right lower parathyroidectomy and partial resection of thyroid gland due to nodular lesions
2006Symptomatic hyperparathyroidism - prathyroidectomy of a recurrent lesion in the area of previously removed right lower parathyroid gland, focal parathyromatosis
2006–2010Acceleration of the hyperparathyroidism and growth of adenomatous lesions – 3 surgeries. Non-specifically increased Ki-67 proliferation index (6%) in histopathological examination of parathyroid adenomas
2010, 2013, 2014Surgical treatment due to adenomatous parathyroid lesions in the right side of the neck
2014Exclusion of the mutation of RET protooncogene, negative staining against parafibromin, advanced stage of nephrocalcinosis in right kidney and lower pole of left kidney, bell-shaped thorax in imaging examination, right sided parathyromatosisSurgical treatment: resection of pathological parathyroid tissue as well as parathyromatosis located in muscles and adipose tissue because of hypercalcaemic crisisFarmacological treatment: calcimimetics – cinacalcet together with zoledronic acid and calcitonin and next denosumab
November 2015Operation of another recurrent lesion, located between the right jugular vein and right common carotid artery. Diagnosis of the parathyroid cancer. Treatment with denosumab and vitamin D
January 2016Pharmacological treatment of severe hypercalcaemia. Exclusion of the germinal mutation of gene CDC73
May 2016Another hypercalcaemic crisis resistant to pharmacological management and emergency surgical (resection of 26mm diameter tumor infiltrating the sternum manubrium) and pharmacological treatment (high doses of zoledronic acid and cinacalcet). Developing the pulmonary embolism
September 2016Operation of another four lesions: three in the cervical area and one located retroclavicularly. Discovery of a somatic mutation CDC73/HRPT2
2017–2019Parathyroidectomy, 33 courses of radiotherapy (fractional dose 2 Gy, total radiation dose 66 Gy on neck and mediastinum region) complicated and additional pharmacological treatment (cinacalcet and denosumab)

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923