14 June 2021
: Case report 
A Young Woman with Excessive Fat in Lower Extremities Develops Disordered Eating and Is Subsequently Diagnosed with Anorexia Nervosa, Lipedema, and Hypermobile Ehlers-Danlos Syndrome
Challenging differential diagnosis, Clinical situation which can not be reproduced for ethical reasons, Rare coexistence of disease or pathology
Thomas F. Wright1BDEF*, Karen L. Herbst2DEFDOI: 10.12659/AJCR.930840
Am J Case Rep 2021; 22:e930840
Table 2. Diagnostic criteria of lipedema: International consensus [8].
| • Onset at puberty, pregnancy, and menopause-progressive with age |
| • Uncontrolled localized fat deposition involving the lower extremities (usually legs and thighs) |
| • Symmetric increase in adipose tissue (“two-body syndrome”) |
| • Tired “heavy” legs |
| • Pain to touch or pressure may be mild or severe |
| • Easy bruising |
| • Hands and feet usually not affected (unlike lymphedema) |
| • Cuffs or bulges develop around joints (eg, ankles, knees, elbows, and wrists) |
| • Negative Stemmer’s sign |
| • Palpable spheroids in lipedema fat |
| • Reduced ambulation, decreased social activity |