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17 May 2021: Articles

Anti-N-Methyl-D-Aspartate Receptor Encephalitis with Serum Anti-Thyroid Antibodies: A Case Report and Literature Review

Challenging differential diagnosis, Diagnostic / therapeutic accidents, Management of emergency care, Unexpected drug reaction , Rare disease, Educational Purpose (only if useful for a systematic review or synthesis)

Emilia Matera A* , Alessandra Gabellone B , Maria Giuseppina Petruzzelli D , Lucia Marzulli F , Flora Furente D , Lucia Margari A

DOI: 10.12659/AJCR.931104

Am J Case Rep 2021; 22:e931104

Table 1. Literature review on anti-NMDArE cases with serum anti-Thy Abs.

AuthorsType of studyPatients (Number, sex, age in years)Abs (type and serum level)TherapyOutcome
Tuzun E et al (2011) []26 Research article2, F, 37 and 53TPO and TG >200 IU/mLSteroids+ IVIG or PLEX or CyclophosphamideNeurological improvement with return to work and daily activities
De Leu N et al (2012) []27 Case report1, F, 16TPO >600 IU/mLMethylprednisolone+ thyroidectomyAfter 3 days of corticoid administration, gradual and complete neurological relapse
Lu J et al (2015) []28 Case report1, F, 36TPO 585 IU/mLMethylprednisolone+ prednisone + PLEXImprovement of psychosis and hypersexuality. At about 5 months, recurrence of Graves’ disease (treated with Methimazole and radioactive iodine ablation) and subjective memory impairment
Jung Y et al (2016) []29 Case report1, F, 70TPO >3000 IU/mLTG 92.52 IU/mLSteroids+ IVIG+ RituximabGradual improvement of confusional mentality and psychiatric symptoms. After 12 months complete resolution of the symptoms
Zhang W et al (2017) []30 Research article1, F, 18TPO 58.43 IU/mL TG 920.33 IU/mLMethylprednisolone+ IVIGPartial recovery of psychological and behavioral disorders (mRS score: 4) after 10 months
Wang X et al (2018) []31 Case report1, F, 20TPO and TG (no data on serum levels)Steroids+ IVIGMarked improvement of mental status without motor or behavioral abnormality
F – Female patient; TPO – thyroperoxidase antibodies; TG – thyroglobulin antibodies; IVIG – intravenous immunoglobulins; PLEX – plasmapheresis.

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923