13 May 2021
: Case report 
Delayed Severe Hemolytic Transfusion Reaction During Pregnancy in a Woman with β-Thalassemia Intermediate: Successful Outcome After Eculizumab Administration
Unusual or unexpected effect of treatment, Diagnostic / therapeutic accidents, Rare coexistence of disease or pathology
Giovanna Cannas1ABCDEFG*, Léa Dubreuil2BD, Axel Fichez3BD, Mathieu Gerfaud-Valentin4BD, Anne-Lise Debard2BD, Arnaud Hot1DDOI: 10.12659/AJCR.931107
Am J Case Rep 2021; 22:e931107
Table 1. Treatment of DHTR with hyperhemolysis by eculizumab in patients with hemoglobinopathy: review of the literature.
| Reference | Patient | Diagnosis | Outcome after eculizumab therapy | Associated treatments |
|---|---|---|---|---|
| Boonyasampat et al []30 | 35-year-old female | SCD | Improvement from day 7 | Ritux |
| Dumas et al []31 | 20-year-old female17-year-old female18-year-old male | SCDSCDSCD | Improvement from day 3Improvement from day 21Improvement from day 1 | EPOPE, EPOIS, CS |
| Chonat et al []32 | 14-year-old female | SCD | Improvement from day 2 | CS, Ig, Ritux, EPO |
| Vlachaki et al []33 | 21-year-old female | SCD | Improvement from day 3 | CS, Ig, Ritux |
| Unnikrishnan et al []34 | 28-year-old female | SCD | Improvement from day 5 | Hemopure |
| Mpinganzima et al []35 | 28-year-old female | SCD | Improvement from day 1 | EPO, Ritux |
| Present case | 39-year-old pregnant female | β-thalassemia intermediate | Improvement from day 3 | Ig, EPO |
| CS – corticosteroids; EPO – erythropoietin; Ig – intravenous immunoglobulins; IS – immunosuppressive regimen; PE – plasma exchange; Ritux – rituximab; SCD – sickle cell disease. | ||||