18 October 2021
: Case report 
Hypercalcemia and CYP24A1 Gene Mutation Diagnosed in the 2nd Trimester of a Twin Pregnancy: A Case Report
Challenging differential diagnosis, Unusual setting of medical care, Rare disease, Clinical situation which can not be reproduced for ethical reasons
Andris Romašovs12ABCDEF*, Lauma Jaunozola1DF, Egija Berga-Švītiņa3CF, Zanda Daneberga3CF, Edvīns Miklaševičs3CD, Valdis Pīrāgs12AEFDOI: 10.12659/AJCR.931116
Am J Case Rep 2021; 22:e931116
Table 1. Laboratory results at the first hospital admission (16 weeks+5 days of gestation) and the follow-up visit during pregnancy.
| Admission date | Day 30 | Day 60 | Reference range | |
|---|---|---|---|---|
| WBC (×10/L) | 10.6 | 9.3 | 8.6 | 4–10 |
| RBC (×10/L) | 3.5 | 3.0 | 2.8 | 4.2–5.4 |
| Hb (g/L) | 103 | 95 | 86 | 120–160 |
| Ht (%) | 30.1 | 28.2 | 25.9 | 37–47 |
| Plt (×10/L) | 155 | 164 | 107 | 150–400 |
| MCV (fL) | 87.4 | 93.8 | 92.2 | 80–100 |
| MCH (pg) | 30 | 31.8 | 30.8 | 27–33 |
| MCHC (g/L) | 343 | 339 | 334 | 320–360 |
| ALT (U/L) | 16 | 10–49 | ||
| AST (U/L) | 20 | 0–33 | ||
| Glucose (mmol/L) | 3.7 | 4.1–5.9 | ||
| Total protein (g/L) | 62 | 64–83 | ||
| Albumin (g/L) | 38 | 35–52 | ||
| Urea (mmol/L) | 4.1 | 5.9 | 7.7 | 3.2–8.2 |
| Creatinine (umol/L) | 80 | 94 | 89 | 49–90 |
| Sodium (mmol/L) | 137 | 140 | 139 | 136–145 |
| Potassium (mmol/L) | 4.1 | 3.9 | 4.4 | 3.5–.5.1 |
| Calcium (mmol/L) | 3.4 | 2.9 | 2.9 | 2.08–2.65 |
| Phosphorus (mmol/L) | 1.0 | 0.9 | 1.0 | 0.78–1.65 |
| Magnesium (mmol/L) | 0.6 | 0.5 | 0.6 | 0.66–1.07 |
| Iron (umol/L) | 18.7 | 9–30.4 | ||
| CRP (mg/L) | <4 | 0–5 | ||
| PTH (ng/ml) | 2.1 | 4.7 | 15–68.3 | |
| TSH (uIU/ml) | 2.9 | 0.55–4.78 | ||
| PTHrP (pg/ml) | <20 | <20 | ||
| 25-OH Vitamin D | 46.45 | 53.58 | 30–100 | |
| 1.25-OH vitamin D (pg/ml) | 148.1 | 19.6–54.3 | ||
| pH | 7.57 | 7.35 | ||
| Sodium | 136 | 136–145 | ||
| Potassium | 3.8 | 3.4–4.5 | ||
| Ionised calcium | 1.75 | 1.15–1.27 | ||
| Urine volume (L/24 h) | 1.9 | |||
| Calcium (mmol/24 h) | 5.6 | |||
| ALT – alanine aminotransferase; AST – aspartate transaminase; CRP – C-reactive protein; GFR – glomerular filtration rate; PTH – parathyroid hormone; PTHrP – parathyroid hormone-related protein; 25-OH vitamin D – 25-hydroxy vitamin D; 1.25-OH vitamin D – 1,25-dihydroxyvitamin D. | ||||