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15 June 2021: Articles

A Case of Rapid Transformation from Hydatidiform Mole to Invasive Mole: The Importance of β-hCG (Human Chorionic Gonadotropin) Serum Levels in Follow-Up Evaluation

Unusual setting of medical care, Rare disease, Educational Purpose (only if useful for a systematic review or synthesis)

Ali Budi Harsono A , Yudi Mulyana Hidayat C , Gatot Nyarumenteng A. Winarno E* , Aisyah Shofiatun Nisa E , Firas Farisi Alkaff E

DOI: 10.12659/AJCR.931156

Am J Case Rep 2021; 22:e931156

Table 1. Reported cases of invasive mole rapid transformation after curettage procedure.

CasePatient’s ageObstetric historyCurrent pregancyInitial β-hCG levelType of hydatidiform moleTime to transform to invasive moleSite of metastasesTreatment for invasive mole
Zou et al, 2012 []7 341 pregnancy16 weeks800 842 mIU/mLPartial3 weeksLung3 cycles of chemotherapy (fluorouracil + dactinomycin)
Martinez Leocadio et al, 2019 []8 537 preganancies684 180 mIU/mLComplete1 weekLung and vaginaHysterectomy → 3 cycles of chemotherapy (Etoposide + Methotrexate + Actinomycin-Oncovin + Cyclophosphamide)
Current case460 pregnancy8 weeks>300 000 mIU/mLCompleteLess than 22 daysInvasive UteryHysterectomy

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923