15 June 2021
: Case report 
A Case of Rapid Transformation from Hydatidiform Mole to Invasive Mole: The Importance of β-hCG (Human Chorionic Gonadotropin) Serum Levels in Follow-Up Evaluation
Unusual setting of medical care, Rare disease, Educational Purpose (only if useful for a systematic review or synthesis)
Ali Budi Harsono1ABCDEFG, Yudi Mulyana Hidayat1CDG, Gatot Nyarumenteng Adhipurnawan Winarno1EF*, Aisyah Shofiatun Nisa1EF, Firas Farisi Alkaff2EFDOI: 10.12659/AJCR.931156
Am J Case Rep 2021; 22:e931156
Table 1. Reported cases of invasive mole rapid transformation after curettage procedure.
| Case | Patient’s age | Obstetric history | Current pregancy | Initial β-hCG level | Type of hydatidiform mole | Time to transform to invasive mole | Site of metastases | Treatment for invasive mole |
|---|---|---|---|---|---|---|---|---|
| Zou et al, 2012 []7 | 34 | 1 pregnancy | 16 weeks | 800 842 mIU/mL | Partial | 3 weeks | Lung | 3 cycles of chemotherapy (fluorouracil + dactinomycin) |
| Martinez Leocadio et al, 2019 []8 | 53 | 7 preganancies | – | 684 180 mIU/mL | Complete | 1 week | Lung and vagina | Hysterectomy → 3 cycles of chemotherapy (Etoposide + Methotrexate + Actinomycin-Oncovin + Cyclophosphamide) |
| Current case | 46 | 0 pregnancy | 8 weeks | >300 000 mIU/mL | Complete | Less than 22 days | Invasive Utery | Hysterectomy |