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15 July 2021: Articles

Isolated Adrenocorticotropic Hormone Deficiency Associated with Severe Hyperkalemia During Pembrolizumab Therapy in a Patient with Ureteral Cancer and an Ileal Conduit: A Case Report and Literature Review

Unusual clinical course

Yudai Hinata B , Nobumasa Ohara A* , Yuhki Sakurai C , Ryo Koda B , Yuichiro Yoneoka C , Toshinori Takada C , Noboru Hara B , Tsutomu Nishiyama B

DOI: 10.12659/AJCR.931639

Am J Case Rep 2021; 22:e931639

Table 1. Serial changes in levels of morning plasma adrenocorticotropic hormone and cortisol, serum electrolytes, and blood eosinophils, immediately before and during pembrolizumab therapy in 2019. All blood samples were collected in the morning.

Early JulyLate JulyMid-AugLate AugMid-SeptEarly OctLate OctLateNov
ACTH (pg/mL)43.145.422.842.262.268.371.216.6
Cortisol (μg/dL)12.511.77.412.212.410.311.41.4
Sodium (mEq/L)144141142143144142142134
Potassium (mEq/L)5.35.45.25.14.54.64.36.3
Chloride (mEq/L)114114117118118116114113
Creatinine (mg/dL)1.581.941.771.781.901.951.831.79
Eosinophils (/μL)139160141159244271316437
White blood cells (/μL)34003800440037003700410040004200
All blood samples were collected in the morning.

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923