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15 July 2021: Articles

Isolated Adrenocorticotropic Hormone Deficiency Associated with Severe Hyperkalemia During Pembrolizumab Therapy in a Patient with Ureteral Cancer and an Ileal Conduit: A Case Report and Literature Review

Unusual clinical course

Yudai Hinata B , Nobumasa Ohara A* , Yuhki Sakurai C , Ryo Koda B , Yuichiro Yoneoka C , Toshinori Takada C , Noboru Hara B , Tsutomu Nishiyama B

DOI: 10.12659/AJCR.931639

Am J Case Rep 2021; 22:e931639

B: Corticotropin-releasing hormone (CRH)/growth hormone-releasing factor (GRF)/thyrotropin-releasing hormone (TRH)/luteinizing hormone-releasing hormone (LHRH) stimulation test (November 2019).

Reference range*BasalPeak (time at peak)
Adrenocorticotropic hormone (pg/mL)7.2–63.311.616.7 (60 min)
Cortisol (μg/dL)7.1–19.62.22.9 (90 min)
Growth hormone (ng/mL)0–2.471.513.6 (15 min)
Thyroid-stimulating hormone (μIU/mL)0.50–5.002.8619.84 (30 min)
Prolactin (ng/mL)6.1–30.520.853.9 (30 min)
Luteinizing hormone (mIU/mL)0.8–5.723.252.6 (90 min)
Follicle-stimulating hormone (mIU/mL)2.0–8.349.862.1 (120 min)
Blood samples were collected in the morning before (basal) and at 15, 30, 60, 90, and 120 min after i.v. administration of the following: 100 μg of CRH, 100 μg of GRF, 500 μg of TRH, and 100 μg of LHRH.

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923