15 July 2021
: Case report 
Isolated Adrenocorticotropic Hormone Deficiency Associated with Severe Hyperkalemia During Pembrolizumab Therapy in a Patient with Ureteral Cancer and an Ileal Conduit: A Case Report and Literature Review
Unusual clinical course
Yudai Hinata1BCD, Nobumasa Ohara1ABCDEF*, Yuhki Sakurai1CD, Ryo Koda2BCD, Yuichiro Yoneoka3CD, Toshinori Takada4CD, Noboru Hara5BD, Tsutomu Nishiyama5BDDOI: 10.12659/AJCR.931639
Am J Case Rep 2021; 22:e931639
Table 3. Laboratory findings on admission in November 2019.
| Total protein | 7.2 g/dL | (6.6–8.1) |
| Albumin | 3.4 g/dL | (4.1–5.1) |
| Creatine phosphokinase | 83 U/L | (41–153) |
| Urea nitrogen | 37.4 mg/dL | (8.0–20.0) |
| Creatinine | 1.79 mg/dL | (0.46–0.79) |
| Sodium | 134 mEq/L | (135–147) |
| Potassium | 6.3 mEq/L | (3.5–4.8) |
| Chloride | 113 mEq/L | (98–108) |
| C-reactive protein | 0.85 mg/dL | (0–0.14) |
| Casual plasma glucose | 119 mg/dL | (70–139) |
| Adrenocorticotropic hormone | 16.6 pg/mL | (7.2–63.3) |
| Cortisol | 1.4 μg/dL | (7.1–19.6) |
| Plasma renin activity | 15.7 ng/mL/h | (0.2–2.3) |
| Aldosterone | 12.3 ng/dL | (3.0–15.9) |
| Arginine vasopressin | 0.9 pg/mL | |
| Thyroid-stimulating hormone | 4.80 μIU/mL | (0.50–5.00) |
| Free thyroxine | 1.46 ng/dL | (0.90–1.70) |
| Free triiodothyronine | 2.57 pg/mL | (2.30–4.00) |
| pH | 7.204 | |
| Bicarbonate ion | 13.0 mmol/L | |
| Partial carbon dioxide pressure | 34.2 mmHg | |
| Partial oxygen pressure | 37.5 mmHg | |
| Base excess | −13.6 mmol/L | |
| Lactic acid | 9.0 mg/dL | |
| Anion gap | 9.8 mmol/L | |
| The reference range for each parameter is shown in parentheses. Blood samples were collected in the morning with the patient in the supine position. | ||