13 October 2021
: Case report 
Epstein-Barr Virus Causing Clinical Jaundice and Acute Acalculous Cholecystitis in a Previously Healthy 17-Year-Old Girl
Challenging differential diagnosis, Rare coexistence of disease or pathology
Kevin G. Harvey1ABCDEFG*, Joshua G. Tice2BCDF, Adam Sigal1ACDEGDOI: 10.12659/AJCR.932285
Am J Case Rep 2021; 22:e932285
Table 1. Laboratory values differentiating between the 3 major types of jaundice (pre-hepatic, intra-hepatic, and post-hepatic).
| Pre-hepatic jaundice (hemolysis) | Intra-hepatic jaundice (infection, congenital abnormality, medication effects, etc.) | Post-hepatic jaundice (cholelithiasis/obstruction) | |
|---|---|---|---|
| Total bilirubin (normal=0.3–1.0 mg/dL) | ↑ | ↑↑ | ↑↑ |
| Conjugated bilirubin (normal=0.0–0.2 mg/dL) | – | ↑ | ↑ |
| Unconjugated bilirubin (normal=0.2–0.8 mg/dL) | ↑ | ↑ | – |
| AST and ALT (normal AST & ALT=typically <40 IU/L) | – | ↑↑ | Normal/slightly ↑ |
| Alk Phos (normal=38–126 IU/L) | – | Normal/slightly ↑ | ↑↑ |
| GGT (normal=8–23 IU/L) | – | Normal/slightly ↑ | ↑↑ |
| Urine bilirubin (normal=absent) | Absent | Present | Present |