Toxic Epidermal Necrolysis Caused by Allopurinol: A Serious but Still Underestimated Adverse Reaction

11 October 2021 : Case report Germany

Rare disease, Adverse events of drug therapy

Daniel Hoyer^1ACDEF*, Carlo Atti^1ABCDE, Sebastian Nuding^1E, Alexander Vogt^1E, Daniel G. Sedding^1E, Artjom Schott^1ABCDE

DOI: 10.12659/AJCR.932921

Am J Case Rep 2021; 22:e932921

Background Case Report Discussion Conclusions References:

Related articles Order reprints Share article Share by email

View HTML version

Table 1. Severity-of-Illness Score for Toxic Epidermal Necrolysis (SCORTEN) at Day 1, 3, and 5.

Parameters	Points d1/d3/d5
Age >40 yrs	1/1/1
HF >120 bpm	1/0/0
Malignancy	0/0/0
Initial epidermal detachement >10%	1/1/1
Serum-urea 10 mmol/L	1/0/0
Serum-bicarbonate <20 mmol/L	0/0/0
Serum-glucose >14 mmol/L	1/0/0
SCORTEN-Points	5/2/2
Mortality (%)	90%/12%/12%
Microsoft Excel 2016 (Microsoft Corporation, Redmond, WA, USA).

Back to the Article