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21 December 2021: Articles

A Neonate with a Diagnosis of Pontocerebellar Hypoplasia Type 6 Treated with Biotin and Developed Biotin Interference with Laboratory Thyroid Function Tests

Unusual clinical course

Motomichi Nagafuji A* , Daisuke Hitaka E , Atsushi Iwabuchi D , Yayoi Miyazono E , Hidetoshi Takada D

DOI: 10.12659/AJCR.934417

Am J Case Rep 2021; 22:e934417

Table 1. Comparison with previously reported neonatal cases in which biotin interfered with laboratory tests.

AuthorAgeSexDiagnosisBiotin doseReason for biotin useMisdiagnosis
Henry et al [] (1996)4 1 dayFemaleNot reported10 mg/day (2.5 mg/kg/day)Organic acidosisGraves disease
Wijerante et al [] (2012)5 1 weekMaleMetabolic disorder30 mg/dayLactic acidosisGraves disease
Bulow et al [](2016)6 1 dayFemaleNewborn failure to thrive5 mg/day (1.7 mg/kg/day)Biotinidase deficiencyGraves disease
Kummer et al [] (2016)7 1 monthMaleMitochondrial disorder7 mg/kg/dayLactic acidosisGraves disease
Kummer et al [] 2016)7 1 monthMaleMitochondrial disorder8 mg/kg/dayLactic acidosisGraves disease
This case14 daysMaleMitochondrial disorder5 mg/day (1.8 mg/kg/day)Lactic acidosisGraves disease

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923