21 December 2021
: Case report 
A Neonate with a Diagnosis of Pontocerebellar Hypoplasia Type 6 Treated with Biotin and Developed Biotin Interference with Laboratory Thyroid Function Tests
Unusual clinical course
Motomichi Nagafuji1ABCEF*, Daisuke Hitaka1EF, Atsushi Iwabuchi12DEF, Yayoi Miyazono
12EF, Hidetoshi Takada12DEF
DOI: 10.12659/AJCR.934417
Am J Case Rep 2021; 22:e934417
Table 1. Comparison with previously reported neonatal cases in which biotin interfered with laboratory tests.
| Author | Age | Sex | Diagnosis | Biotin dose | Reason for biotin use | Misdiagnosis |
|---|---|---|---|---|---|---|
| Henry et al [] (1996)4 | 1 day | Female | Not reported | 10 mg/day (2.5 mg/kg/day) | Organic acidosis | Graves disease |
| Wijerante et al [] (2012)5 | 1 week | Male | Metabolic disorder | 30 mg/day | Lactic acidosis | Graves disease |
| Bulow et al [](2016)6 | 1 day | Female | Newborn failure to thrive | 5 mg/day (1.7 mg/kg/day) | Biotinidase deficiency | Graves disease |
| Kummer et al [] (2016)7 | 1 month | Male | Mitochondrial disorder | 7 mg/kg/day | Lactic acidosis | Graves disease |
| Kummer et al [] 2016)7 | 1 month | Male | Mitochondrial disorder | 8 mg/kg/day | Lactic acidosis | Graves disease |
| This case | 14 days | Male | Mitochondrial disorder | 5 mg/day (1.8 mg/kg/day) | Lactic acidosis | Graves disease |