28 January 2022
: Case report 
Secondary Hemophagocytic Lymphohistiocytosis in a Neonate with SARS-CoV-2 Infection
Challenging differential diagnosis, Rare disease, Clinical situation which can not be reproduced for ethical reasons
Hasan Zuhair El-Isa
1ABDEF*, Osama As’ad Khader1ACDEF, Mustafa Khader 1ADEF, Bahaa Abed Ashour2ABDE, Muayad Imad Azzam 1ADEF, Eman Farouk Badran 2ABDE
DOI: 10.12659/AJCR.934839
Am J Case Rep 2022; 23:e934839
Table 1. CBC levels details from day 2 to day 40 of life.
| Day of life | Hb (g/dl) | RBC (million/mm3) | WBC (cell/mm3) | Lymphocyte (%) | Lymphocyte count (cell/mm3) | Neutrophils (%) | ANC (cell/mm3) | Platelets ×109/L |
|---|---|---|---|---|---|---|---|---|
| Normal ranges | 13–20 | 5.1–5.3 | 5000–21 000 | 48 | 2400– 10 080 | 40–80 | 2000–16 800 | 150 000–450 000 |
| 2 | 17.0 | 5.59 | 1.96 | 44.3 | 0.87 | 41.1 | 0.8 | 101 |
| 4 | 11.5 | 4.16 | 0.43 | 28.0 | 0.12 | 3.3 | 0.014 | 124 |
| 5 | 12.7 | 4.51 | 0.61 | 38.0 | 0.23 | 8.0 | 0.048 | 104 |
| 7 | 11.9 | 4.41 | 0.70 | 36.0 | 0.25 | 26.0 | 0.180 | 216 |
| 10 | 10.8 | 3.78 | 0.86 | 66.0 | 0.57 | 24.0 | 0.200 | 365 |
| 17 | 10.7 | 4.70 | 0.73 | 47.0 | 0.34 | 0.0 | 0.000 | 458 |
| 21 | 8.8 | 3.19 | 0.88 | 46.0 | 0.40 | 1.0 | 0.008 | 210 |
| 23 | 9.0 | 3.28 | 1.14 | 44.0 | 0.50 | 4.0 | 0.045 | 186 |
| 28 | 6.2 | 2.17 | 1.02 | 70.0 | 0.71 | 20.0 | 0.200 | 110 |
| 29 | 10.8 | 3.76 | 1.08 | 72.0 | 0.78 | 14.0 | 1.080 | 80 |
| 34 | 7.8 | 2.78 | 1.00 | 80.0 | 0.80 | 10.0 | 0.100 | 98 |
| 36 | 9.7 | 3.17 | 0.89 | 38.0 | 0.34 | 6.0 | 0.053 | 44 |
| 37 | 11.4 | 3.70 | 0.58 | 73.4 | 0.43 | 14.1 | 0.080 | 40 |
| 38 | 11.5 | 3.90 | 0.33 | 70.0 | 0.23 | 20.0 | 0.066 | 35 |
| 39 | 9.4 | 3.07 | 0.47 | 33.0 | 0.16 | 12.0 | 0.056 | 58 |
| 40 | 8.1 | 2.71 | 0.35 | 60.0 | 0.21 | 24.0 | 0.084 | 40 |
| Hb – hemoglobin level; RBC – red cell count; WBC – weight cell count; ANC – absolute neutrophil count. | ||||||||