Transient Complete Blindness Due to Metformin-Associated Lactic Acidosis (MALA) Reversed with Hemodialysis

Libardo Rueda Prada; Lindsey Knopps; Igor Dumic; Christopher Barusya; Anand Subramanian; Antonios Charokopos; Adel S. Zurob

doi:10.12659/AJCR.935730

18 April 2022: Articles

Transient Complete Blindness Due to Metformin-Associated Lactic Acidosis (MALA) Reversed with Hemodialysis

Mistake in diagnosis, Management of emergency care, Rare disease, Adverse events of drug therapy, Clinical situation which can not be reproduced for ethical reasons

Libardo Rueda Prada ^A* , Lindsey Knopps ^E , Igor Dumic ^A , Christopher Barusya ^E , Anand Subramanian ^E , Antonios Charokopos ^E , Adel S. Zurob ^E

DOI: 10.12659/AJCR.935730

Am J Case Rep 2022; 23:e935730

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Background Case Report Discussion Conclusions References:

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Table 1. Summary of PubMed database of case reports of MALA with transient vision loss.

Case Author	Year of publication	Country	Age (years)	Sex	Presence of diabetes	Presence of CKD	Baseline creatinine (mg/dL)	Hypothermia	Hypotension
Kreshak et al []⁸	2010	USA	67	F	Yes	Yes	1.3	Yes	No
Cigarrán et al []⁹	2012	Spain	54	M	Yes	Yes	1.14	No	Yes
Jeon et al []¹⁰	2019	Korea	68	M	Yes	Not reported	Not reported	Yes	No
Ryu et al []¹¹	2019	Korea	68	M	Yes	No	0.75	Yes	No
Kalantri et al []¹²	2020	USA	77	F	Yes	Yes	1.4	No	Yes
Case Author	Encephalopathy	GI tract symptoms	Respiratory distress	Peak creatinine (mg/dL)	Peak lactate	Lowest pH	Dialysis required	Vision loss outcome
Kreshak et al []⁸	No	No	Yes	7	19.9	6.65	Yes	Recovered
Cigarrán et al []⁹	Yes	Yes	Yes	9.13	15.07	6.96	Yes	Recovered
Jeon et al []¹⁰	No	Yes	No	2.31	>11	6.78	Yes	Recovered
Ryu et al []¹¹	No	Yes	No	2.31	>11	6.78	Yes	Recovered
Kalantri et al []¹²	Yes	Yes	Yes	6.16	23.8		Yes	Recovered

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Transient Complete Blindness Due to Metformin-Associated Lactic Acidosis (MALA) Reversed with Hemodialysis

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