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22 October 2022: Articles

Association Between Parafibromin Expression and Presence of Brown Tumors and Jaw Tumors in Patients with Primary Hyperparathyroidism: Series of Cases with Review of the Literature

Challenging differential diagnosis, Unusual setting of medical care, Rare disease, Congenital defects / diseases, Educational Purpose (only if useful for a systematic review or synthesis), Rare coexistence of disease or pathology

Michał Popow A , Monika Kaszczewska A , Magdalena Góralska B , Piotr Kaszczewski B* , Agata Skwarek-Szewczyk B , Witold Chudziński B , Krystian Jażdżewski B , Monika Kolanowska B , Magdalena Bogdańska B , Aleksandra Starzyńska-Kubicka B , Zbigniew Gałązka E

DOI: 10.12659/AJCR.936135

Am J Case Rep 2022; 23:e936135

Table 2. Results of the staining against parafibromin and selected clinical features of the patients.

Patient IDStainingOther data
NuclearCytoplasmicControl stainingClinical dataGenetic data
Proportion scoreIntensity scoreCytoplasmic stainingStaining in other cellsMedical conditionCDC73 mutation
100YesPresentPHPT and brown tumorsCDC73 germline
20NoPresentPHPT and brown tumorsCDC73 germline
454YesPresentPHPT and brown tumorsMEN1 germline
Proportion scoring was as follows: – no cells are positive; – ≤1% of cells are positive; – 1–10% of are positive; – 11–33% of cells are positive; – 34–66% of cells are positive; – 67–100% of cells are positive. Intensity scoring was as follows: – negative; – weak; – intermediate; – strong.

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923