22 October 2022
: Case report 
Association Between Parafibromin Expression and Presence of Brown Tumors and Jaw Tumors in Patients with Primary Hyperparathyroidism: Series of Cases with Review of the Literature
Challenging differential diagnosis, Unusual setting of medical care, Rare disease, Congenital defects / diseases, Educational Purpose (only if useful for a systematic review or synthesis), Rare coexistence of disease or pathology
Michał Popow1ABCDEF, Monika Kaszczewska12ABCDEF, Magdalena Góralska1BCD, Piotr Kaszczewski2BCDEF*, Agata Skwarek-Szewczyk
1BCD, Witold Chudziński 2BD, Krystian Jażdżewski34BCD, Monika Kolanowska3BCD, Magdalena Bogdańska5BCD, Aleksandra Starzyńska-Kubicka 5BCD, Zbigniew Gałązka2EF
DOI: 10.12659/AJCR.936135
Am J Case Rep 2022; 23:e936135
Table 2. Results of the staining against parafibromin and selected clinical features of the patients.
| Patient ID | Staining | Other data | ||||
|---|---|---|---|---|---|---|
| Nuclear | Cytoplasmic | Control staining | Clinical data | Genetic data | ||
| Proportion score | Intensity score | Cytoplasmic staining | Staining in other cells | Medical condition | CDC73 mutation | |
| 1 | 0 | 0 | Yes | Present | PHPT and brown tumors | CDC73 germline |
| 2 | 0 | <1 | No | Present | PHPT and brown tumors | CDC73 germline |
| 3 | 0 | 0 | No | ND | HPTJT | Absent |
| 4 | 5 | 4 | Yes | Present | PHPT and brown tumors | MEN1 germline |
| Proportion scoring was as follows: – no cells are positive; – ≤1% of cells are positive; – 1–10% of are positive; – 11–33% of cells are positive; – 34–66% of cells are positive; – 67–100% of cells are positive. Intensity scoring was as follows: – negative; – weak; – intermediate; – strong. | ||||||