17 April 2022: Articles
Complete Plaque Regression in Patients with Peyronie’s Disease After Multimodal Treatment with Antioxidants: A Report of 2 Cases
Unknown etiology, Unusual clinical course, Mistake in diagnosis, Unusual or unexpected effect of treatment, Congenital defects / diseases, Educational Purpose (only if useful for a systematic review or synthesis)
Gianni Paulis A* , Giovanni De Giorgio EDOI: 10.12659/AJCR.936146
Am J Case Rep 2022; 23:e936146
Table 1. Case summaries of 2 patients with Peyronie’s disease treated by multimodal therapy.
| No. | Patient age | Comorbidities | Penile plaque site | Ultrasound measurements (length × width × thickness) and plaque volume, before A) and after treatment B) | Type of deformity initial (A) and after treatment (B) |
|---|---|---|---|---|---|
| 1 | 50 years | None | Distal third | ||
| 2 | 55 years | High cholesterol, penile lichen sclerosus, congenital (5-degree) dorsal penile curvature | Distal third | ||
| IIEF – International Index of Erectile Function; VAS – visual analogue pain score; PTX – pentoxifylline. | |||||
| No. | Pain score/VAS scale (1–10) | IIEF score before and after treatment | Total duration of treatment until plaque regression | Complete combined multimodal treatment | |
| 1 | VAS score=2 disappeared after 6 months | 26 >28 | 39 months | Propolis 600 mg +Bilberry 160 mg +Silymarin 400 mg +Ginkgo biloba 250 mg +Vitamin E 800 UI/daily/for 39 months + Diclofenac gel 4%/2× daily/for 39 months + PTX 100 mg (30 G needle) 2× per month for 6 months and then 1× per month for 12 months and then 1× every 2 months for 12 months (30 total injections) for 30 months | |
| 2 | VAS score=0 | 26 >28 | 39 months | Propolis 600 mg +Bilberry 160 mg +Silymarin 400 mg +Ginkgo biloba 250 mg +L-Carnitine 1000 mg +Coenzyme Q10 100 mg +Vitamin E 30 mg/daily/for 39 months+ Diclofenac gel 4%/2× daily/for 39 months + PTX 100 mg (30 G needle) 2× per month for 6 months and then 1× per month for 12 months and then 1× every 2 months for 12 months (30 total injections) for 29 months | |
| IIEF – International Index of Erectile Function; VAS – visual analogue pain score; PTX – pentoxifylline. | |||||