06 July 2022
: Case report 
Clozapine-Induced Myocarditis in a Young Man with Refractory Schizophrenia: Case Report of a Rare Adverse Event and Review of the Literature
Unusual clinical course, Unusual or unexpected effect of treatment, Adverse events of drug therapy, Educational Purpose (only if useful for a systematic review or synthesis)
Adebola Oluwabusayo Adetiloye1ADEF*, Wael Abdelmottaleb1ABDEF, Mirza Fawad Ahmed1BDEF, Ana Maria Victoria1BE, Mustafa Bilal Ozbay
1DE, Julio C. Valencia Manrique1EF, Rasha Alaameri1E, Olurotimi Badero2DE, Savi Mushiyev13DE
DOI: 10.12659/AJCR.936306
Am J Case Rep 2022; 23:e936306
Table 1. Dose titration and duration of antipsychotics treatment prior to onset of myocarditis symptoms.
| Name of antipsychotic and dosage | Duration of treatment |
|---|---|
| 1. OLANZAPINE | 50 days |
| Dose titration: | |
| Olanzapine 10 mg daily | 1 dose |
| Olanzapine 15 mg daily | 10 doses |
| Olanzapine 20 mg daily | 7 doses |
| Olanzapine 20 mg twice daily | 24 doses |
| Olanzapine 15 mg daily | 7 doses |
| Olanzapine 5 mg daily | 2 doses |
| 2. CLOZAPINE 20 days | |
| Dose titration: | |
| Clozapine 12.5 mg twice daily | 8 doses |
| Clozapine 25 mg twice daily | 10 doses |
| Clozapine 50 mg twice daily | 8 doses |
| Clozapine 75 mg twice daily | 10 doses |
| Clozapine 100 mg twice daily | 4 doses |
| 3. LITHIUM 450 mg twice daily | 7 days |
| 4. HALOPERIDOL 10 mg injection PRN | 1 day |