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06 July 2022: Articles

Clozapine-Induced Myocarditis in a Young Man with Refractory Schizophrenia: Case Report of a Rare Adverse Event and Review of the Literature

Unusual clinical course, Unusual or unexpected effect of treatment, Adverse events of drug therapy , Educational Purpose (only if useful for a systematic review or synthesis)

Adebola Oluwabusayo Adetiloye A* , Wael Abdelmottaleb A , Ahmed Fawad Mirza B , Ana Maria Victoria B , Mustafa Bilal Ozbay D , Julio C. Valencia Manrique E , Rasha Alaameri F , Olurotimi Badero D , Savi Mushiyev D

DOI: 10.12659/AJCR.936306

Am J Case Rep 2022; 23:e936306

Table 1. Dose titration and duration of antipsychotics treatment prior to onset of myocarditis symptoms.

Name of antipsychotic and dosageDuration of treatment
1. OLANZAPINE50 days
Dose titration:
  Olanzapine 10 mg daily1 dose
  Olanzapine 15 mg daily10 doses
  Olanzapine 20 mg daily7 doses
  Olanzapine 20 mg twice daily24 doses
  Olanzapine 15 mg daily7 doses
  Olanzapine 5 mg daily2 doses
2. CLOZAPINE 20 days
Dose titration:
  Clozapine 12.5 mg twice daily8 doses
  Clozapine 25 mg twice daily10 doses
  Clozapine 50 mg twice daily8 doses
  Clozapine 75 mg twice daily10 doses
  Clozapine 100 mg twice daily4 doses
3. LITHIUM 450 mg twice daily7 days
4. HALOPERIDOL 10 mg injection PRN1 day

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923