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27 May 2022: Articles

Postoperative Serotonin Syndrome Following Administration of Preoperative Intrapulmonary Methylene Blue and Intraoperative Granisetron: A Case Report

Unusual clinical course, Unexpected drug reaction

Wei-Hsiu Huang E , Min-Jia Li E*

DOI: 10.12659/AJCR.936317

Am J Case Rep 2022; 23:e936317

Table 2. Drug Interaction Probability Scale [16].

Questions
1.Are there previous credible reports of this interaction in humans?
2.Is the observed interaction consistent with the known interactive properties of precipitant drug?
3.Is the observed interaction consistent with the known interactive properties of object drug?
4.Is the event consistent with the known or reasonable time course of the interaction (onset and/or offset)?
5.Did the interaction remit upon dechallenge of the precipitant drug with no change in the object drug? (If no dechallenge, use Unknown or NA and skip Question 6)
6.Did the interaction reappear when the precipitant drug was readministered in the presence of continued use of object drug?
7.Are there reasonable alternative causes of the event?
8.Was the object drug detected in the blood or other fluids in concentrations consistent with the proposed interaction?
9.Was the drug interaction confirmed by any objective evidence consistent with the effects on the object drug (other than drug concentrations from question 8)?
10.Was the interaction greater when the precipitant drug dose was increased or less when the precipitant drug dose was decreased?
* NA – not applicable.

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923