27 May 2022>: Articles
Postoperative Serotonin Syndrome Following Administration of Preoperative Intrapulmonary Methylene Blue and Intraoperative Granisetron: A Case Report
Unusual clinical course, Unexpected drug reaction
Wei-Hsiu Huang E , Min-Jia Li E*DOI: 10.12659/AJCR.936317
Am J Case Rep 2022; 23:e936317
Table 2. Drug Interaction Probability Scale [16].
Questions | |
---|---|
1. | Are there previous credible reports of this interaction in humans? |
2. | Is the observed interaction consistent with the known interactive properties of precipitant drug? |
3. | Is the observed interaction consistent with the known interactive properties of object drug? |
4. | Is the event consistent with the known or reasonable time course of the interaction (onset and/or offset)? |
5. | Did the interaction remit upon dechallenge of the precipitant drug with no change in the object drug? (If no dechallenge, use Unknown or NA and skip Question 6) |
6. | Did the interaction reappear when the precipitant drug was readministered in the presence of continued use of object drug? |
7. | Are there reasonable alternative causes of the event? |
8. | Was the object drug detected in the blood or other fluids in concentrations consistent with the proposed interaction? |
9. | Was the drug interaction confirmed by any objective evidence consistent with the effects on the object drug (other than drug concentrations from question 8)? |
10. | Was the interaction greater when the precipitant drug dose was increased or less when the precipitant drug dose was decreased? |
* NA – not applicable. |