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29 June 2022: Articles

Acute Hepatitis with Positive Autoantibodies: A Case of Natalizumab-Induced Early-Onset Liver Injury

Unusual clinical course, Challenging differential diagnosis, Unusual or unexpected effect of treatment, Diagnostic / therapeutic accidents, Unexpected drug reaction , Educational Purpose (only if useful for a systematic review or synthesis)

Marlone Cunha-Silva ** , Priscilla Brito Sena de Moraes * , Pedro Rodrigues de Carvalho A , Larissa Bastos Eloy da Costa B , Guilherme Rossi Assis-Mendonça B , Cristina Alba Lalli B , Gisele Conte Alves Fernandes B , Fernanda Bocchi Monteiro B , Gustavo Manginelli Lamas B , Alfredo Damasceno B , Daniel Ferraz de Campos Mazo C , Tiago Sevá-Pereira D

DOI: 10.12659/AJCR.936318

Am J Case Rep 2022; 23:e936318

Table 2. Main features of our case and others previously published.

AgeGenderDoses to the eventDays after the first dosePrevious therapies beyond CEAntibodiesAuthor
60F11IFN-β, DMF, FLMANA, ASMAOur case
51F33IFN-βASMAMartínez-Lapiscina []4
26F2ASMAAntezana []5
31F2IFN-βANALisotti []6
26F1NaNaNaKader []11
52F2NaNaKader []11
26F16NaNaBezabeh []1
43M5NaANABezabeh []1
33F118IFN-βASMABezabeh []1
59F18NaNaBezabeh []1
50F1~14IFN-β, GACASMA, ANA, AMABezabeh []1
58M12IFN-βNaBezabeh []1
F – female; M – male; CE – corticosteroids, IFN-β – interferon-beta; DMF – dimethyl fumarate; FLM – fingolimod; Na – not available; ANA – anti-nuclear antibody; ASMA – anti-smooth muscle antibody; AMA – anti-mitochondrial antibody; GAC – glatiramer acetate.

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923