29 June 2022>: Articles
Acute Hepatitis with Positive Autoantibodies: A Case of Natalizumab-Induced Early-Onset Liver Injury
Unusual clinical course, Challenging differential diagnosis, Unusual or unexpected effect of treatment, Diagnostic / therapeutic accidents, Unexpected drug reaction, Educational Purpose (only if useful for a systematic review or synthesis)
Marlone Cunha-Silva ** , Priscilla Brito Sena de Moraes * , Pedro Rodrigues de Carvalho A , Larissa Bastos Eloy da Costa B , Guilherme Rossi Assis-Mendonça B , Cristina Alba Lalli B , Gisele Conte Alves Fernandes B , Fernanda Bocchi Monteiro B , Gustavo Manginelli Lamas B , Alfredo Damasceno B , Daniel Ferraz de Campos Mazo C , Tiago Sevá-Pereira DDOI: 10.12659/AJCR.936318
Am J Case Rep 2022; 23:e936318
Table 2. Main features of our case and others previously published.
Age | Gender | Doses to the event | Days after the first dose | Previous therapies beyond CE | Antibodies | Author |
---|---|---|---|---|---|---|
60 | F | 1 | 1 | IFN-β, DMF, FLM | ANA, ASMA | Our case |
51 | F | 33 | – | IFN-β | ASMA | Martínez-Lapiscina []4 |
26 | F | 2 | – | – | ASMA | Antezana []5 |
31 | F | 2 | – | IFN-β | ANA | Lisotti []6 |
26 | F | 1 | Na | Na | Na | Kader []11 |
52 | F | 2 | – | Na | Na | Kader []11 |
26 | F | 1 | 6 | Na | Na | Bezabeh []1 |
43 | M | 5 | – | Na | ANA | Bezabeh []1 |
33 | F | 1 | 18 | IFN-β | ASMA | Bezabeh []1 |
59 | F | 1 | 8 | Na | Na | Bezabeh []1 |
50 | F | 1 | ~14 | IFN-β, GAC | ASMA, ANA, AMA | Bezabeh []1 |
58 | M | 12 | – | IFN-β | Na | Bezabeh []1 |
F – female; M – male; CE – corticosteroids, IFN-β – interferon-beta; DMF – dimethyl fumarate; FLM – fingolimod; Na – not available; ANA – anti-nuclear antibody; ASMA – anti-smooth muscle antibody; AMA – anti-mitochondrial antibody; GAC – glatiramer acetate. |