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27 July 2022: Articles

Hypoprothrombinemia During Cefmetazole Treatment: A Case Report

Unusual clinical course, Challenging differential diagnosis, Unusual or unexpected effect of treatment, Diagnostic / therapeutic accidents, Adverse events of drug therapy, Educational Purpose (only if useful for a systematic review or synthesis)

Yuichiro Haba A* , Hikaru Akizuki A , Naoyuki Hashiguchi A , Toshio Naito A

DOI: 10.12659/AJCR.936712

Am J Case Rep 2022; 23:e936712

Table 3. Naranjo scale of adverse drug reaction probability. Underlining is applied for our study.

QuestionnaireYesNoDo not know or not done
1. Are there previous conclusive reports of this reaction?00
2. Did the adverse event appear after the drug was given?−10
3. Did the adverse reaction improve when the drug was discontinued or a specific antagonist was given?00
4. Did the adverse reaction reappear upon readministering the drug?−1
5. Were there other possible causes for the reaction?−10
6. Did the adverse reaction reappear upon administration of placebo?−1+1
7. Was the drug detected in the blood or other fluids in toxic concentrations?+10
8. Was the reaction worsened upon increasing the dose? Or, was the reaction lessened upon decreasing the dose?+10
9. Did the patient have a similar reaction to the drug or a related agent in the past?+10
10. Was the adverse event confirmed by any other objective evidence?00
Total score in our study7
≥9: definite adverse drug reaction1–4: possible adverse drug reaction0: doubtful adverse drug reaction

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923