24 August 2022: Articles
An 80-Year-Old Man with Ischemic Heart Disease Who Developed Thrombotic Thrombocytopenic Purpura Following Treatment with Ticagrelor
Challenging differential diagnosis, Diagnostic / therapeutic accidents, Management of emergency care, Rare disease, Adverse events of drug therapy , Educational Purpose (only if useful for a systematic review or synthesis)
Simone A. Jarrett A* , Ammaar Wattoo A , Brenda Chiang A , Gabor Varadi D , Mohammad Al Madani ADOI: 10.12659/AJCR.936977
Am J Case Rep 2022; 23:e936977
Table 1. Comparison of laboratory test results from our case and prior cases of ticagrelor-associated TTP in the literature.
| Lab values (unit) | Our case | Case 1 (2017) [14] | Case 2 (2018) [7] |
|---|---|---|---|
| Hemoglobin (g/dL) | 8.7 | 8.4 | 7.7 |
| Platelets (per mm) | 40 | 20 000 | 38 000 |
| LDH (U/L) | 562 | 1074 | 13 976 |
| AST (IU/L) | 273 | 7392 | |
| ALT (IU/L) | 313 | 3947 | |
| Indirect Bili (mg/dl) | 0.5 | 19.8 | |
| BUN (mg/dl) | 159 | 44.7 | |
| Serum creatinine (mg/dl) | 4.8 | 2.62 | |
| INR | 1.3 | ||
| Haptoglobin (mg/dl) | 10 | ||
| Fibrinogen (mg/dl) | 307 | 246 | |
| ADAMTS13 activity (%) | 55 | 48.1 | |
| LDH – lactate dehydrogenase; AST – aspartate aminotransferase; ALT – alanine transferase; Bili – bilirubin; BUN – blood urea nitrogen; INR – international normalized ratio. | |||